Basic Information

Symbol
GNLY
RNA class
mRNA
Alias
Granulysin TLA519 NKG5 D2S69E LAG-2 LAG2 T-Lymphocyte Activation Gene 519 T-Cell Activation Protein 519 Lymphokine LAG-2 Lymphocyte-Activation Gene 2 Protein NKG5
Location (GRCh38)
2:85685175-85698852
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006433.5
Sequence length
777.0 nt
GC content
0.5740

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-281.90 kcal/mol
Thermodynamic ensemble
Free energy: -295.45 kcal/mol
Frequency: 0.0000
Diversity: 179.26
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..((.((((((.(((((.........)))))(((..((((...((..((((((((((((.((((..((((((((((((((((..((..((((((((((...(((((...(((((((((((((((((......)))....))).)))).))))))).....)))))...)))))...((((....))))))...)))..))..)))))))))))...)))))...((((......))))..(((((((((..(((......((((.((((....))))))))......(((.((((.(((.(((...(((....(((((..((........(((((.(.(((((((.((.((((((((..((((((((.(((.((((.(((((.((.(((((.....))))).)).))..)))))).....).)))))))))))(.(((..((((...)))).))).)(((...)))((.((((((....((((((((((.(.....((((....))))....).))))))))))..)))))).)))))))))))).).))))))...).))))))))))))..))))))))))))).)))..........)))..))))).))))...(((((((.(((.((.((((((.((.(((....)))...........(((.((((...((((....))))..))))))).)).))))...)).)).))).))))).)))))).)))))).))))))..)).))))..)))...)))))).))........
Thermodynamic Ensemble Prediction
..,,.((((({.,||||}.{,,,..,||||},,((,((((.,.((..((((((((((((.((((.{{{{..(((((((((((..((..(((,{(((((...(((((...((((((((((((((({(.,....)))....))).)))).))))))).....)))))...)))))...((((....)))),,...)))..))..)))))))))))..{(({.{{|.((((......)))}.,(((((((({..({{......(((,,((((....)))))))).....,{.....||..(((((......)))))(((((..,,,.......(((((.(.(((((((.((.((((((((({(((({(((.(((.{{{|.((({(.((.{{{{(.,,.,))|||.}|.,,..,}}},),}}..}.})))))))))){.{{{..((((...)))).))).}|{{}}}))){(.((((((....((((((((((.{.....((((....))))....}.))))))))))..)))))).)))))))))))).).))))))...).))))),,)))))}}))))))},}}}}}.}}|.....|,...,,,,,},,})}),)),,.{,{((((.(((.((.{{{{((.((,(((.,,,}||,....,{,,..,{(,{{{{...{{((....)))).,))))})}.)).)))}..,)),)).))).))))),)))))).)))))).))))))..)),))))}}.,....}))))).,),},.....

Transcripts

ID Sequence Length GC content
NM_001302758.2 NCBI
AAGCUGCAGGCUCCCUGCCCAUAAAACAGGGUGUGAAAGGCAUCUCAGC… 858 nt 0.5734
NM_006433.5 NCBI
AAGCUGCAGGCUCCCUGCCCAUAAAACAGGGUGUGAAAGGCAUCUCAGC… 777 nt 0.5740
NM_012483.4 NCBI
AAGCUGCAGGCUCCCUGCCCAUAAAACAGGGUGUGAAAGGCAUCUCAGC… 1021 nt 0.5779
Summary

The product of this gene is a member of the saposin-like protein (SAPLIP) family and is located in the cytotoxic granules of T cells, which are released upon antigen stimulation. This protein is present in cytotoxic granules of cytotoxic T lymphocytes and natural killer cells, and it has antimicrobial activity against M. tuberculosis and other organisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans demonstrated that the GNLY is a lysosome-related gene whose expression was significantly higher in peripheral blood from normal controls compared to sepsis patients, and high expression correlated with a higher 28-day survival rate in sepsis patients, with single-cell RNA sequencing localizing its high expression specifically to T cells and NK cells [Chen et al. DOI:10.1186/s12865-023-00588-7]. A review of mouse and human studies noted that the GNLY is an effector molecule from CD8+ T-cells that promotes apoptosis and endothelial cell shedding, leading to plaque erosion [Xinxin Bian et al. DOI:10.3892/mmr.2025.13680].