Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. [provided by RefSeq, Jul 2008]
Forensic Context
A study in mice demonstrated that the GPC5 is a susceptibility gene for inflammatory demyelinating diseases and is specifically expressed in oligodendrocyte precursor cell (OPC) subclusters 1 and 2, which were the subpopulations most responsive to post-mortem interval (PMI)-induced perturbations [Guo et al. DOI:10.1016/j.ijbiomac.2025.147708].