This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008]
Forensic Context
A study in mice demonstrated that the GPR183 is part of the microglial sensome and was significantly downregulated at 14 days post-injury in a controlled cortical impact model of traumatic brain injury [Izzy et al. DOI:10.3389/fncel.2019.00307].