Basic Information

Symbol
GPX3
RNA class
mRNA
Alias
Glutathione Peroxidase 3 Extracellular Glutathione Peroxidase Glutathione Peroxidase 3 (Plasma) Plasma Glutathione Peroxidase Selenoprotein GPX3 EC 1.11.1.9 GSHPx-3 GSHPx-P GPx-P GPx-3 EC 1.11.1 GPXP
Location (GRCh38)
5:151020591-151028988
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Mechanical injury analysis Cause of death analysis Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002084.5
Sequence length
1603.0 nt
GC content
0.5565

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-596.00 kcal/mol
Thermodynamic ensemble
Free energy: -624.36 kcal/mol
Frequency: 0.0000
Diversity: 367.73
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((((..((((((((((((((((..((.((((((((....)))))).((((((.....((((((((((((((((.(((((((((....(((.(((............))).)))..))))).))))))))))).........((((.......)))).))))))))).....).))))).......(((((.((((..(((.(((((((((((((........)))))......(((((.((((((...(((((...........)))))))))))))))).(((((...)))))(((.((((......)))).)))......(((((((.((((....((((.((.(((((((((.((((((((...((....((.....))))...)))).)))).))))))....................))).)))))).)))).)))))))((((((..(((((((....))).)))))))))))))))))).)))..(((((((((....(((((.((((((.(((...(((.........((((.((.((((.((((...((((.(((((((......(((((......)))))..(((.(((((((((((((....))))))).))))))((..(((((.....)))))..))((((.....((((.....))))))))...))).....(((((...))))).....)))))))))))..)))).)))).))..))))..........)))...)))(((((((((........(((((((((((..(((((...((.(((.....((((........))))..))).))....))))).)))))))))))((((((..((((((((((((((...(((((.((.....)))))))....)))))))).)).)))).)))))))))).)))))...((((((((((...((.(....).))...))))))))))(((((((((.(((......))).))))))))).......)))))).))))).......((.(((((.(((((((.((.((((((.((.((......)).)).)))))).)).))).....(((.......)))......(((........))).......)))).))))).))....))))))))).(((((((........((((((.(((.........))).)))))).)))))))......(((....)))((((((....))))))........................)))))))))..(((.(((((((((.((((..............((((..(((.(((....((..(((.......)))..)).....))).))))))).......((((....).)))...(((((((((((((((((((.(.((((((..((....((((....)))))).)))))))))))(((((((.(((((((((((.............))))..))))))))))))))))))))))))))))))))).)))))....))))))))).))..))))))).)))))........))))))))))((.(((.(((....))))))..)).
Thermodynamic Ensemble Prediction
((((((..((((((((((((((((..((.((((((((....)))))).((((({.....((((((((((((((((.(((((((((....(((.(((............))).)))..))))).))))))))))}.........((((.......)))),))))))))).....).))))).......(((((.((((.,,((,....|||{(((({(,.{.{(((((((({,,..(((((.((((((...(((((.,.....,...)))))))))))))))).(((((...)))))(((.((((......)))).)))...((((((((((.((((....((((.((.(((((((((.((((((((...((....{|.....}}))...)))).)))).))))))|,....,,.,.,......}.))).)))))).)))).))))))).})).....,{,{{.....,}),)})))))))))),..{((,(({..(((((((((....(((((.(((((({(((,{.{{,,..,,,,..((((.({.((((.((((...((((.(((((((...{{{(((({....,.}||||.|{,,..,{{{{(((((({....}))))))||||||,((||(((((.....}}))},|||{|||||.|||||{,....}}))}}}}...}||.....(((({...})))).....))))))))))}..)))).)))).))..))))........,.}||..,|,,{{{{{((((..,.,|,,{((((((((((..(((((...((.(((.....((((........))))..))).))....))))).))))))))))}{,{{{...((((((((((((((...(((((.({.....},)))))....)))))))).)).)))),)}))))})))|))))),..((((((((((..,((.{....},))...))))))))))|((((((((.(((......))).))))))))).}))},.}))))).))))).,,..,,{(.(((((.((((({(.((.((((((.((.({......}}.)).)))))).)).}},.....{{{.....,.,,,......(((........))).....,})))).))))).))..,,))))))))).,{(({,,,,{{,...,|||||.||{.........})),)}))),.,,|||||......{||,,..))}((((((....)))))).........)))})},........))))))))),.||,|((({{{{||.,{{(,{{{{{{..,........,.((({.,,,,(.({{......}}}.}}}))},,......))..))))))......,(((,.{,{..|||,..(((((((((((((((,{({.{.((({((,,{(,...((((....)))))).)))))))))),(((((((.(((((((((((.............))))..)))))))))))))))))))))))))))))}}}}.))})}.,}}))))),.}),))..))))))).)))))........))))))))))((.(((.{{,....}}})))..)).

Transcripts

ID Sequence Length GC content
NM_001329790.2 NCBI
AGACGGACGGUGGCCAGGGAUCAGGCAGCGGCUCAGGCGACCCUGAGUG… 1630 nt 0.5589
NM_002084.5 NCBI
AGACGGACGGUGGCCAGGGAUCAGGCAGCGGCUCAGGCGACCCUGAGUG… 1603 nt 0.5565
Summary

The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies, including thyroid cancer, hepatocellular carcinoma and chronic myeloid leukemia. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]

Forensic Context

A study in mice demonstrated that the GPX3 gene, an oxidative stress marker, was up-regulated in gastrocnemius muscle following both local hind limb and distant dorsum burn injuries, with increased expression observed at 6 hours, 1 day, and 3 days post-local burn and at 6 hours, 12 hours, 1 day, 2 days, 7 days, and 10 days post-distant burn [Padfield et al. DOI:10.01.ta.0000230567.56797.6c]. A study in mice demonstrated that in vivo exposure to α-particles specifically targeting Kupffer or endothelial liver cells induced an inflammatory state, with the GPX3 being commonly up-regulated following these exposures [Roudkenar et al. DOI:10.1269/jrr.07078]. This up-regulation was part of a characteristic gene expression profile distinct from chemical hepatotoxicants, validated by real-time PCR, indicating its role in the hepatic response to radiation.