Basic Information

Symbol
GSTK1
RNA class
mRNA
Alias
Glutathione S-Transferase Kappa 1 GST13 GST Class-Kappa GST 13-13 GSTK1-1 HGSTK1 Glutathione S-Transferase Subunit 13 Homolog Glutathione S-Transferase Subunit 13 Glutathione S-Transferase K1 EC 2.5.1.18 GST13-13 GST
Location (GRCh38)
7:143244093-143270873
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_015917.3
Sequence length
1032.0 nt
GC content
0.5446

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-359.30 kcal/mol
Thermodynamic ensemble
Free energy: -378.44 kcal/mol
Frequency: 0.0000
Diversity: 243.38
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((.(((((((.((..((((.(((((((((....(((.(((((((((((....(((((...)))))..)))))).))))).)))((((.(((((.((((((((..(((.((.(((.........))))).)))..)))))))).).....))))))))..........))))))).....)).))))..)).))))))).))......(((.((.((((((.((.(((((.((.(((....))).)).))))((.....)).....(((((((.((((......((((((((.(((.(..(((((((..((......((((((.((((.(((.(......).))).)))).....))))))...((((..((((...(((((((....))))....))))))).))))))..)))))))..).))).))))))))(((((((....((((((...((((.(((((((((.(((.(((((((((.((((((((((((.((...((((((....(((((((((.....((((((((.(((((.((...(.((....((((...))))..)).)....)).))))).)).))).)))...)))))))))...))))))))))))))).....(((.(((.(((((((..........)))))))...((((((..(.((.((.(((((.....(((.((.(((((........))))).)).)))......))))).)))).)..))))))..........))))))(.((((......)))).).......((((((.....))))))..(((.((.((........)).))..)))..((((((......))))))...))).)).)))))))))..)))))..))))).)).))))(((.......)))..))))))....))))))))))).)))))))((((.............)))).....).)).))))))..)).)))..............................((((....)))).....
Thermodynamic Ensemble Prediction
.(,((((.(((((...))))),)})},,(((((,(((.(((((((((((....(((((...)))))..)))))).))))).))),,.({((,.{{((({({,,|||}}}|,.||||,{{{{({,,......(((((((((.(((....,,((,..{((.(((({...))))).}}....}),.}}}}))).))))))))).......,))),,,.,{,,(({(..((((,.,,.,,,}}}}}))})|,}}}}..},{((((....((((((((.((((......((((((((.(((.(..(((((((..((..,,,........{{{|}},..},,,((((.(((((((.({..,(((((,.{{,.....,.)),,))))|(((....)))}..}).)))))))))))))..)))))))..).))).))))))))(((((((,...((((({...((((.(((((((,{.(((.(((((((((,,(((({({((({,{{,.{((((((,,{,(((((((((.....((((((((.(((((.({...,.{{....((((...))))..)}......)).))))).)).))).)))...))))))))),,,||||}}|{||||||,.....,,|}|||}|{(((((.,,.....,.)))))},...,{{|||,,|.,,{((.(((((.,,..(((.((.(((((........))))).)).)))...,,.))))).)))}.,.,))))),}},,.....,}}}}||{|{|.|....,}))}},,.......((((((|...}))))))..(((.,{{((........,)}),..)))..{{((((..,,,,|}}}}),,,))).}}.))))))))).,}))},}.))))).)).)))){({.......})).,))))))..,.))))))))))).))))))))....))))}.......,||,.....})})}})}}))}})|}}.}},....}}}))))))...............((((....)))).....

Transcripts

ID Sequence Length GC content
NM_001143679.2 NCBI
AGAAGCUGGGCAGCCUCUGCCGGGUUCCGGGAAAAGGAGCUCCUGCUGC… 1200 nt 0.5542
NM_001143680.2 NCBI
AGAAGCUGGGCAGCCUCUGCCGGGUUCCGGGAAAAGGAGCUCCUGCUGC… 996 nt 0.5432
NM_001143681.2 NCBI
AGAAGCUGGGCAGCCUCUGCCGGGUUCCGGGAAAAGGAGCUCCUGCUGC… 903 nt 0.5548
NM_015917.3 NCBI
AGAAGCUGGGCAGCCUCUGCCGGGUUCCGGGAAAAGGAGCUCCUGCUGC… 1032 nt 0.5446
Summary

This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]

Forensic Context

A study in porcine (Yorkshire crossbred swine) skin demonstrated that the GSTK1 was significantly increased at 24 hours following a 45-second cutaneous bromine exposure, as part of the NRF2-mediated oxidative stress signaling pathway [Price et al. DOI:10.1016/j.toxlet.2008.08.007].