Basic Information

Symbol
GSTO1
RNA class
mRNA
Alias
Glutathione S-Transferase Omega 1 GSTTLp28 P28 Glutathione-Dependent Dehydroascorbate Reductase Glutathione S-Transferase Omega 1-1 Glutathione S-Transferase Omega-1 S-(Phenacyl)Glutathione Reductase Monomethylarsonic Acid Reductase MMA(V) Reductase EC 2.5.1.18 GSTO 1-1 SPG-R Epididymis Secretory Protein Li 21 Glutathione-S-Transferase Like EC 1.20.4.2 EC 1.8.5.1 HEL-S-21 GSTTLP28 GSTO-1
Location (GRCh38)
10:104235356-104267461
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004832.3
Sequence length
813.0 nt
GC content
0.4945

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-266.10 kcal/mol
Thermodynamic ensemble
Free energy: -283.54 kcal/mol
Frequency: 0.0000
Diversity: 203.22
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
......((((....((((...((((.(((((.((.((.....)).)).).))))))))))))))))(((((((((((.(((((((((......))))).)))).))..((.(((.......))).))((((((((.((((((((...(((...(((((..(((.(((((((((((.(((((..(((.((.....)).))).)))))......((((.....))))............)))).))))))).....)))..))))).....)))....))))).(((((.(.(((((....((((..((((((((((((...........))))).....((((((((((((((((....(((((((...((((((((..(((((((((((((.....)))))))))..)))).))))))))...((((.((((..((((..(((........)))..))))))))..))))..))))))).((((((..((..(((((((((((((((..((....)).)))..)))))))))))))).))))))(((.....)))........))))))))).........)))))))...(((......)))....(((((((.....))))))).....((((.(((((((....(..((.....))..)...))))))).))))...)))))))..))))...))))).)..)))))...((((((((((.((((((....(((....))))))))).)).))))))))))).))))))))(((((..(((....)))..))))).))))))))).....
Thermodynamic Ensemble Prediction
.....{((({...,((((,..{(((.(((((.((.((.....)).)).).))))))))))))))))|((((((({((.(((((((((,....,))))).)))).)).,{{,{.{({.(((((,{.((,...||)}.,.)))))}}(((((.......)))))..(((((((((({.(((((,.(({.,{......,.}}}.}})))......,|||,,...}}}|,,...,,,....))))))))))))..{{(({{{,(((,....}}},|{{{{|{|||{||||,.{.{{{{{,,|.((((..(((((({(((((.,,...,,,..)))))....,(((({{{(((((((((...,{,.{{{({((((((((({..(((((((((((((.....)))))))))..)))),}})))}}..}})))}.{||{..((((..(((........)))..))))}},,..,,,,...||}|||.{|{{||},|{..{((((((((((((((..,,....}}.)),.,))))))))))))}}.}}}|}}{{{.....)}}.},,..,,)))))))))..,,,,,,.,,}}|||{,.{{{......}}}....(((((((.....))))))).....((((.(((((((,,..,..((.....))..,,},))))))).))))...)))))))..))))...}))))})},.,||||{{{((((((({{.((((((....(((....))))))))).}}.))))))),.}))))))|||}((((({.,{,....)}),.))))).,)))))))}.....

Transcripts

ID Sequence Length GC content
NM_001191002.2 NCBI
GCAAACCCCAGAGGAGCUCGGCCUGCGCUGCGCCACGAUGUCCGGGGAG… 714 nt 0.5098
NM_001191003.2 NCBI
GCAUUUUUCUCCAGCGAGAGGAAGGAUGACUCCUAGACCUGUCUUUGUC… 1069 nt 0.4668
NM_004832.3 NCBI
GCAAACCCCAGAGGAGCUCGGCCUGCGCUGCGCCACGAUGUCCGGGGAG… 813 nt 0.4945
Summary

The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Forensic Context

A study in humans identified the GSTO1 as a highly expressed core gene in sepsis patients, localized to macrophages and involved in inflammatory and immune responses [Wang et al. DOI:10.2147/IDR.S380137]. A separate review of human studies noted the GSTO1 is part of a six-protein panel, analyzed via UPLC-MS/MS, demonstrating high diagnostic accuracy for sudden cardiac death risk in hypertrophic cardiomyopathy [Raluca-Maria Cătinas; Sorin Hostiuc DOI:10.3390/ijms26146818]. A separate review of human forensic studies reported that the GSTO1 is part of a validated six-protein panel, analyzed via UPLC-MS/MS, which demonstrates high diagnostic accuracy for assessing sudden cardiac death risk in patients with hypertrophic cardiomyopathy [Raluca-Maria Cătinas et al. DOI:10.3390/ijms26146818].