Basic Information

Symbol
GSTT2
RNA class
mRNA
Alias
Glutathione S-Transferase Theta 2 (Gene/Pseudogene) Glutathione S-Transferase Theta-2 GST Class-Theta-2 Glutathione S-Transferase Theta 2 EC 2.5.1.18
Location (GRCh38)
22:23980058-23983915
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden unexpected death diagnosis Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000854.5
Sequence length
1108.0 nt
GC content
0.5523

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-389.00 kcal/mol
Thermodynamic ensemble
Free energy: -410.42 kcal/mol
Frequency: 0.0000
Diversity: 285.96
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((..(((...((((((((((((.((((((..(((((....(((((((((...(((....((((((((.(((..(((....(((..((((....))))..)))....(((((.....(((((.....)))))))))).......)))..))).)).))))))....)))..))))))))).(((((((.....))))))).((((((...((((.((((....(((((.(((...((..((((....))))....))...))))))))..)))).)......(((((((((.((..((((.(((((....))))).....)))))).)))).))))).(((.(.(((((((.(((((((.....((...((.(((...(((..(((((((..((...(((((.((((.((((.....)))).)))).....))))))))))))))...)))...)))))...))..))))..))))))))))).)))(((((..(((((((((((..((..((((.....))))..))))))).).)))))))))).......))))))))).)))))..)))))).))))).)).).)))))))...))))).....((((((((((...(((..(((..(((((((((((.((.....(.(((((.((((.(((.((((........((((((.((.((.((......)))).)).))))))....)))).))).))))..)))))).....((((....)))).....)).))))))))))))))....)))(((....)))((((((.(((((..(((((..(((.((..((...((((..................))))...))..)).)))..)))))....))))).)))))).....((((((....))))))((((.(((....(((((...))))).)))))))((((((.(((.....)))))))))..........(((.(((.((...................))))).)))...(((......)))((((((((.......((((....))))..)))))))).....((((....))))......))))))))))....
Thermodynamic Ensemble Prediction
(((((..({{..{((((((((((((.((((((..(((((....(((((((((...(((....((((((((.,{{,,(({,...,,{.,((((.{,.}|})|,}}}..,.(((((.....(((((.....))))))))))........}}.}))}.)).))))))....)))..))))))))).(((((((.....))))))).(((({,.,{((({{((({....(((((.(((({{((((((,....}))))}}},.,,..,}})))))..)))).,......|({((((({.({..{{((.(((((....))))).,...}}}}}}.)))}}|))}}.(((.(.((((({{,{{,((((,,,.,{{..,((.,((...(((..((((((,.,((...(((((.((((,((({,....}})),)))).,,..))))))))))))))...)))...)))))...))..)))),,}}})))))}}|,))}(((((..((((({(((((..((..((((.....))))..))))))).}.))))))))))...,.},))})))))}.)))))..)))))).))))).)).)}})))))}...))))).....{(((((({((({,(((..(((..(((((((((((.(({....{,(((((.((((.(((.((((........((((((.((.({.{{......}})).)).))))))..,.)))).))).))))..))))),.....((((....))))....,)).))))))))))))))....))),{{.,,})},((((((.(((((..((((({.(((,{,.,(({(,,,,({,.....}})))),,),.))}))))))...................))))).)))))).....{{((((,,,,}}}|||((((.,,,.{{{(((((...))))),)))))}|((((((.(((.....)))))))))}.........({{.(({.,....}}},,.........})))))}.}||...,{{,,.,,,)))||((((((.......((((....))))..))))))))...,,|{{,....}}}},||,,.,}}}},,,,,....

Transcripts

ID Sequence Length GC content
NM_000854.5 NCBI
AGCUGCUGCCCACACCGCGCUCAGCGCCUUCACUGCCAUCCCCGCUGUC… 1108 nt 0.5523
NM_001302670.1 NCBI
AACCGAAGGGGCGAGGCGGGUCCGGGGGUGGUGCGCUCCAAUUGGGUGC… 1189 nt 0.5576
Summary

The protein encoded by this gene, glutathione S-transferase (GST) theta 2 (GSTT2), is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1, GSTT2, and GSTT2B. GSTT2 and GSTT2B are nearly identical to each other, and share 55% amino acid identity with GSTT1. All three genes may play a role in human carcinogenesis. The GSTT2 gene is a pseudogene in some populations. [provided by RefSeq, Sep 2015]

Forensic Context

A study in humans demonstrated that a differentially methylated region in proximity to the GSTT2 gene was identified in cardiac tissue when comparing sudden unexplained death and sudden unexpected death in epilepsy cases, though this finding was noted using a less stringent statistical threshold [Steffan Noe Christiansen et al. DOI:10.3390/ijms22062790]. Research in rats showed that the GSTT2 gene exhibited significantly altered expression in liver tissue on day 4 following a 20% total body surface area burn injury [Jayaraman et al. DOI:10.1016/j.jss.2007.05.025].