Basic Information

Symbol
GZMA
RNA class
mRNA
Alias
Granzyme A CTL Tryptase Fragmentin-1 CTLA3 HFSP Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated Serine Esterase 3) Cytotoxic T-Lymphocyte-Associated Serine Esterase-3 Cytotoxic T-Lymphocyte Proteinase 1 Hanukah Factor Serine Protease) Granzyme 1 H Factor HF Granzyme A (Cytotoxic T-Lymphocyte-Associated Serine Esterase-3; Hanukah Factor Serine Protease) Hanukkah Factor EC 3.4.21.78 Granzyme-1 EC 3.4.21
Location (GRCh38)
5:55102646-55110252
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006144.4
Sequence length
896.0 nt
GC content
0.4275

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-245.90 kcal/mol
Thermodynamic ensemble
Free energy: -260.53 kcal/mol
Frequency: 0.0000
Diversity: 219.76
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.......((((((((((..(((((((.((.(((((((..(((((...((...........))..))))).....(((((((((((((.((((...(((((.....((....)).......)))))..))))))))))).....((((.((((((((.((.(((((.(((((((((..(((((((((.......((((((..((.((((((............((((..(((((.(((((....))))).(((......)))((((((((.....))))))))....)))))..))))...))))))..))..)))))).....)))))))))..))))...........((((.(..((((((.....(.((((((........)))))).).))))..))..).))))...............((((.......))))...(((....)))))))).)))))....((.(((((((((.((((.((((((((((((.(((((..(((....)))..))))).)))((((...(((......))).))))...(((((.(.((((....))))).)))))...................))))))))))))).....))))))))).))..(((((.((((..((.((((.(..((((((((((((((............))))))))))))))..).))))))..))))...)))))...)).)))))......))).)))).(((....)))...(((((.....(((((......)))))))))).))))))((((........))))((((((((.(((.....))).))))))))........))))))).))...)))...)))).....))))))))))..........
Thermodynamic Ensemble Prediction
..,{{{{(((({{((((,.{((((((.((.((({(((,,(((((...((...........))..))))).....{{|||||,|||{|,{|||,},|||||}}}}}||,,.,,|{{{{{,,.||||..|||||}}|}||{{{.{(((({(,,,,,,(,((.,{{{{,|||{{((((..(((((((((.......((((((..((.((((((............((((.,(((((.(((((....))))).{{{......}}|((((((((.....)))))))),...))))),.))))...))))))..))..)))))).....)))))))))..))))........,,,{((,,{,,,,{{{(,,,.,{,({((((..,,....}}||||,,,||||{.||{...}|||....,.........,|}|....}}}.}}}{{,.(((....)))})))}.}))))....((.(((((((((.(({((((((((((((((.(((((..(((....)))..))))).)))((((...(((......))).))))...(((((.(.((({....))))}.))))).|.................))))))))))))).....))))))))).)).,||,.||||||,.}}}||{{{{..((({{{{{{{{||{.....,,,,,,,|||||}}}}))))),},.))))))}}))))}.}))))}.,,||{||}},......|||.||,,.{||.}},)))}}.(((((.....(((((......)))))))))).}}}}}}|{{{........}}}}((((((((.(((.....))).)))))))),||,....})))))),)),,,),}}}))))).....}}}}}}}}}}.,....,...

Transcripts

ID Sequence Length GC content
NM_006144.4 NCBI
AGAUUUUCAGGUUGAUUGAUGUGGGACAGCAGCCACAAUGAGGAACUCC… 896 nt 0.4275
Summary

Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans identified the GZMA as a potential diagnostic biomarker for sepsis, where its expression was significantly higher in healthy control groups compared to sepsis patients across multiple datasets [Li et al. DOI:10.3389/fimmu.2024.1445858].