Basic Information

Symbol
GZMB
RNA class
mRNA
Alias
Granzyme B CTSGL1 CGL1 SECT HLP T-Cell Serine Protease 1-3E Cathepsin G-Like 1 CGL-1 CSP-B CTLA1 CCPI CSPB Granzyme B (Granzyme 2, Cytotoxic T-Lymphocyte-Associated Serine Esterase 1) Cytotoxic T-Lymphocyte Proteinase 2 Cytotoxic Serine Protease B Human Lymphocyte Protein Fragmentin-2 EC 3.4.21.79 C11 Cytotoxic T-Lymphocyte-Associated Serine Esterase 1 Lymphocyte Protease Fragmentin 2 Granzyme 2 Granzyme-2 EC 3.4.21 CTLA-1 GRB
Location (GRCh38)
14:24630954-24634267
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004131.6
Sequence length
891.0 nt
GC content
0.5309

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-293.80 kcal/mol
Thermodynamic ensemble
Free energy: -310.58 kcal/mol
Frequency: 0.0000
Diversity: 215.81
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...((((..(((((((..((((....)))).))).......))))..(((((((((((((((((.(((((....((((((((..(.(((((...((((((((((.(((((((..........((((((((.((.(((((((((((.....))))))...)))))..)).)).)).))))))))))).)).((((((.....)))))).(.((((......(((((((((...(((((............(((((...)).)))............)))))...)))))))))......)))).).........))))))...................))...)))))..)..)))).))))...))))).)))).).)))))).)))))).(((.((((.(((...((((.((((((((.(((.....((((.(((...))).)))).....))))).))))))((((((((((.....)))))).((((......)))).......((((.(((.(..((((....(((((((.((((((......)).))))...............(((....)))((((((..((((.((((((((((((((((..........((((((...)))))).)))))).((((.((((((.....)))))).)))).........)))))))))).))))..)))))).....(((...))))))))))....))))..).)))))))((.(((..........)))))....(((.((.......)).)))......))))((((.(((((.(((.....)))((((((......)))))).))))).)))).)))))))))))..))).........(((......)))))))...
Thermodynamic Ensemble Prediction
........((((((,.(((,((,{..|.}}.{(({.....,.(((..(((((((((((((((((.(((((....((((((((..(.(((((...,,(((((({{.(((((((.{{{.,..,,{{((({{,.,,.|||{,,{{{|,,|,,.,}})}|{{{|}}}},})),,}.)).))))))))))).)).{(((((.....)))))}.{.((((......(((((((((...(((((.....,,.....{(((,...}}.,,,...,........)))))...)))))))))......)))).}.........))))))...................)}...)))))..)..)))).))))...))))).)))).)})))))),,))))).))).|,||}}}}((((({,.((((((((.(((.....((((.(((...))).)))).....))))).)))))).,..)))))).,}.)))..)))))).....{{{(({......,(,,{(((({({..,((..{{(((({((.,,,(({..{{{{}|{{|||{{{{{.,,,,,,...{{{....}},((((((..((((.((((((((((((((((..........{(((((...,})))),)))))).((((.((((((.....)))))).)))).........)))))))))).))))..)))))),..{,{{{...}}})})))},{{{{||,,...}))))),.,,.(((..........))),,....(((.{{......,)}.)))......,||.{{{|,|{{{{.{{,.....,}}{{|||{...,,,)))))),)),))})}}},||{{|,}}.}}..))).,,...)))))))},}.))}))),....

Transcripts

ID Sequence Length GC content
NM_001346011.2 NCBI
AGCUCCAACCAGGGCAGCCUUCCUGAGAAGAUGCAACCAAUCCUGCUUC… 904 nt 0.5288
NM_004131.6 NCBI
AGCUCCAACCAGGGCAGCCUUCCUGAGAAGAUGCAACCAAUCCUGCUUC… 891 nt 0.5309
Summary

This gene encodes a member of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016]

Forensic Context

A study in humans demonstrated that the GZMB is a lysosome-related gene whose expression in peripheral blood is significantly higher in normal controls compared to sepsis patients, with high expression correlating with a higher 28-day survival rate in sepsis patients [Chen et al. DOI:10.1186/s12865-023-00588-7]. In a separate review of mouse and human studies, the GZMB was identified as an effector molecule from CD8+ T-cells that promotes apoptosis and endothelial cell shedding, leading to plaque erosion [Bian et al. DOI:10.3892/mmr.2025.13680].