Basic Information

Symbol
ALOX5AP
RNA class
mRNA
Alias
Arachidonate 5-Lipoxygenase Activating Protein FLAP Arachidonate 5-Lipoxygenase-Activating Protein MK-886-Binding Protein Five-Lipoxygenase Activating Protein
Location (GRCh38)
13:30713478-30765072
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Mechanical injury analysis Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001629.4
Sequence length
869.0 nt
GC content
0.4707

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-247.00 kcal/mol
Thermodynamic ensemble
Free energy: -264.52 kcal/mol
Frequency: 0.0000
Diversity: 220.80
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((((((......))))))))...((((((((((((....((((.((((((.((((......((((..........((((((...(((((......(((..((((((..(((......((((.((((..((((.........))))....)))).)))).....)))..((((((((((((((((...((((((.(.((....)).))))))).((((.......))))......(((..((((.(((((((..((((........((((((((((((.((((((((...)))))))))).(((....)))((((((.((((((((((((((((..((((...))))))))))...))))))...)))).).....))))))))))))....)))........))))..)))))))))))..)))..)))))))....))))).)))).................(((.(((((.....))))))))..................))))))..))).(((((...((((..((.(((....................))))).)))).)))))............)))))))))))..)))).....)))))))))).))))....)))))))...(((((((((((.........)))))))))))))))).((((((((...(((..(((((....(((((((((.((..((((((((((.((........)).).))).))))))..))..))))...))))).((((((((((((.......(((....((((.((.(.(((....))).).)).))))...)))........))))))))))))))).)).))))))))))).
Thermodynamic Ensemble Prediction
.,,,.,(((((((((((.,{(((((((((((((((((....((((.((((({,((((......{{({........,,((((((...{{,{({{{,{{((({,{,{|||..........,{{{(,((((..{(({.,....,,,)}))...,)))},))})..{|||||||,,,(((((((((((({,,,({({((.{.{|,..,||.||}}}}}.{|{|,,.,,,,|}}}......{,,..||||,(((((((..((((..,.....((((((((((((.((((((((...)))))))))),,{{....}||((((({.((((((((((((((({.{((({...)))}})))))...))))))..,}}}}.},,,.}))))))))))))....)))........))))..))))))),,,)}}))),}))))}},..}})),})}))}}.................{((.(((((.....)))))))}.,|||,...........,}},}|}..}}}.(((((...((((..,..{{{.................,..))},,.)))).)))))............,,,,,)))))},}))}).....)))))))))).))))....)))))))...{((((((((((,,....,,.}))))))))))))))).))))).,...})))),})))},...(((({({{{.{{..((((((((({.,,.......,)}.},)))},)))}}..},..}}})...))))).((((((((((((.......(((..,.((((.((.(.(((....))).).)).))))...)))........))))))))))))..,.,,.,,,....,},,.

Transcripts

ID Sequence Length GC content
NM_001204406.2 NCBI
AUCUGGGCAUUUGGAGGUGAAGGGGUCACAGCUCUGGCAAAGAUGGGGU… 1218 nt 0.4828
NM_001629.4 NCBI
CUGUACAGGGCAGGUUGUGCAGCUGGAGGCAGAGCAGUCCUCUCUGGGG… 869 nt 0.4707
Summary

This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]

Forensic Context

A study in humans demonstrated that the ALOX5AP mRNA marker exhibits a blood-specific expression pattern and is stable and detectable in 13–16-year-old blood stains from large (~0.75 cm²) stains but not from small (~0.05 cm²) stains [Zubakov et al. DOI:10.1007/s00414-008-0249-z]. In a separate investigation of human circulating leukocytes following major blunt trauma, the ALOX5AP was identified among the top ten up-regulated genes [Brandfellner et al. DOI:10.1097/SHK.0b013e31829de02f]. A study in humans using peripheral blood samples from heat stroke patients identified the ALOX5AP as a core ferroptosis-related diagnostic biomarker [Yin et al. DOI:10.1186/s12920-025-02188-3].