Basic Information

Symbol
HAVCR1
RNA class
mRNA
Alias
Hepatitis A Virus Cellular Receptor 1 TIM-1 TIMD1 TIM1 KIM1 Kidney Injury Molecule 1 HAVCR-1 HAVCR CD365 T-Cell Immunoglobulin Mucin Family Member 1 T-Cell Immunoglobulin Mucin Receptor 1 T-Cell Membrane Protein 1 TIMD-1 KIM-1 TIM T-Cell Immunoglobulin And Mucin Domain-Containing Protein 1 T Cell Immunoglobin Domain And Mucin Domain Protein 1 CD365 Antigen HAVcr-1
Location (GRCh38)
5:157025939-157069396
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001173393.3
Sequence length
1623.0 nt
GC content
0.4393

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-423.30 kcal/mol
Thermodynamic ensemble
Free energy: -457.46 kcal/mol
Frequency: 0.0000
Diversity: 487.45
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((.......))...(((((((((((((..(((((.((((.....(((((.((...(((((....((((..((((....))))))))....))))).....)).))))).....))))..)))))..(.((((((((((((((...(((((((...))))).))(((..(((.((((((.((((...(((((........)))))............(((((.((((((((.(((.(((......((((((((((..((.((((.(((((((((...((((((((((((((((((.................)))))).....(((((.((((.((((....))))...((((((((((....).)))))))))..((((((...))))))((((((((....((((((...(((((((....))..(((((((.(((.((..((((.(((((((.((((.....)))).))))).....))))))....)).))))))))))((((((((..........((((((.(((((((.(((((((((..((.(((((................(((((((.(((((((......)).)))))...))))))))))))....))..)).)))..))))..)))))))))).))))))))))).....((((.....))))....)))))...))))))........((((.....))))..(((((.((..........)).)))))(((.((((.....)))))))(((........)))))))..))))..(((((((............))))))).((.((((.....)))).))......((((......(((((......))))).......))))))))..)))))......))))))))..)))).))))))..)))..))))))..)))).((((((.....((......)).....)))).))..((((....))))...))))))(..(((....)))..).))).))).)))))))))))))............((((.(((((((...))))...(((....)))((......)).((((((((.(((.((((((.((((((.........(((((.(((((.((.(((.(((((((((((((((............(((((.....)))))((((((..(((((((...))))))).(((............))).((((...)))))))))).....(((((..(((((((((.((.(((......))))).)))))).)))...)))))......))))))))((((...))))...))))))).))).)))))))))))))))))).))))))....)))..))))))))......(((((.......)))))((((.(((.(((((((......)))))))))).))))))).))))..)))).))))))))).))).((((((...((..(((.....)))..)).........)))))).(((((((.....(((.....))).....)))))))....(((.((((((...)))))).)))...)))))))))))))).).)))))).....))))))).......
Thermodynamic Ensemble Prediction
,,....{{{{{{{{(((((,(((((,{{,{((((.((((.,...(((((.((...(((((....((((..((((....))))))))....))))).....)).))))).....})))..)))))..{,(((((({{(({{{{|.,{{{{{{{...|||||,|}{,({{(((,((((({.((({...(((((.,....,.))))),,,,,,},.{(((..((((((..,.,...{{{,,......(((((((.(((((((((.(((((((,,((.,{(({{(((((((.((({({((((.{{{{..,.{,.,,,||.....})))}))),}}}}|{{{....,}}},,{((((((((((....),})))))))).|{(((({...}))))|{|{{||||,|..((((((...((((({{....||..(((((((.(((.{,..((({,(((((((.((((.....)))).))))),....))))))....},.))))))))))((((((((.,........(({(((.(((((((.(((((((((({((.{,,.{||,...,}},)||.,|{((((((.(((((((......)).)))))...)))))))})},},...,|,.|.,||.,,}}))..})))}))))).))})))))))).....{,{,.....}))),...)))))...))))))........{(({{..........|||||.{|....,.....}}.||||}{{{.{{{{.....}))}}}},,|.,...,.,}||},.,.,}.,...(((((({............})))))),((,({{{.....)))).||,,.,,,((((......(((((......))))),,.....)))}.}}}.}}}.)))))})})))).)}...})))})),,.......{{{{.{{....}).}))),{{,,...((.{{{...,.....}))).}},||||........,....,,||||........)))).)))))))))))))))),,{.,{({{,,,...............|||||,..)}}},..(((....))))))....})))))..)))}..,,.{(((((.((((((...,,.,,.(((((.(((({{((.(((.(((((((,{,{{(({.,,,,.,{{,,,,((({.....|||||((,,,{..(((((((...))))))).|||}||,......,.}|,.((({...})))))))},..,,.(((((..(((((((((.{{.(({.....,)}}}}.)))))).)))...)))))....,,}}}}))))||{|,,,})))}..))))))).))).)))))))))))))))))).))))))..,,}),.{||||,,}},....,||||.....,{{||,|{((((.(((.(((((((......)))))))))).)))))}}}|||...}))).)}))))}},.}|),},..,,,.}))))}}}}}}..}))})))..,..........{{{(.,,,|}}}...,{{,{,.{|||...{{|||}}|,...,{{{.{{{(({...,}}}}}.,}),,,))))|}}}}))),,.,.}}}}..)}}}}.,,)))),,}.,,.

Transcripts

ID Sequence Length GC content
NM_001173393.3 NCBI
GCUAUUACUGCAUAUGAUGUAGGUUUAGUUUUCCAAGUUCUUCCGUGGC… 1623 nt 0.4393
NM_001308156.2 NCBI
GCUAUUACUGCAUAUGAUGUAGGUUUAGUUUUCCAAGUUCUUCCGUGGC… 1710 nt 0.4415
NM_012206.3 NCBI
GACCAGGAGUCAGUUUGGCGGUUAUGUGUGGGGAAGAAGCUGGGAAGUC… 1713 nt 0.4507
Summary

The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. The protein is a receptor for multiple other viruses, including Ebola virus, Marburg virus, Dengue virus, and Zika virus and is a possible entry factor for SARS-CoV-2 and other coronaviruses. [provided by RefSeq, Sep 2021]

Forensic Context

A study in rats demonstrated that kidney injury molecule-1 (KIM-1) mRNA and protein levels were dramatically increased in kidney tissue and urine after burn injury and were further augmented during subsequent burn sepsis, correlating with elevated serum creatinine and serving as a predictive marker of acute kidney injury [Yu et al. DOI:10.007/s00068-022-02124-5]. In a separate rat model of blast-induced extremity trauma, KIM-1 (Havcr1) mRNA was upregulated in the kidney at 6 and 24 hours post-injury in both tourniquet and non-tourniquet models, identifying it as an established kidney injury biomarker in this context [Rowe et al. DOI:10.3390/ijms26167794]. A study in Sprague-Dawley rats and NRK-52E cells demonstrated that burn sepsis-induced acute kidney injury significantly upregulated urinary and kidney tissue levels of the HAVCR1 (KIM-1), alongside serum creatinine and inflammatory mediators [Yu et al. DOI: 10.007/s00068-022-02124-5].