Basic Information

Symbol
HCRT
RNA class
mRNA
Alias
Hypocretin Neuropeptide Precursor PPOX OX Prepro-Orexin Preprohypocretin Orexin Hypocretin (Orexin) Neuropeptide Precursor Hypocretin (Orexin) Neuropeptide Orexin Precursor Hypocretin NRCLP1 PPORX Hcrt
Location (GRCh38)
17:42184060-42185452
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001524.1
Sequence length
577.0 nt
GC content
0.6846

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-241.90 kcal/mol
Thermodynamic ensemble
Free energy: -252.37 kcal/mol
Frequency: 0.0000
Diversity: 154.05
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.......((((((.(((.(((..(((((..((((........))))..............(((...........))))))))..))).)))..........(((...(((((...)))))...)))..((....)).((.(..((((.(((.(((((((((((....).)))...))))))).)))))))..).))......))))))......(((((((((.(((((...(((..(.((((.(((.(((((((........))).))))))).....((((((((...((((((((((((....))))))))))..((((((((((((......))))))(((.(((((......))))).)))...)))))).(((((((((.....)))((.((((.((((..((((((.......)))))))))))))).)).((((.(((.((....)).))).))))((((((....(((.((((((......)))))))))))))))))))))(((....)))....))...)))))))))))).)..))).....)))))...)).))))))).....
Thermodynamic Ensemble Prediction
......,((((((.(((,(((,,(((((..{{((........}}}}.............{(,,..........})),)))))..}}}.,))|||||.....,,,.,,|||{,...||||},,.||}..((....)).||.|,.((((.(((.((((((({(({....,.))}..,))))))).)))))))....)),,}...))))))}.....((((((({(,(((((...(((..{.((((.(((.(((((((........)))}})))))).....((((((((...((((((({{.(((((.,,(((((,|({,((((((((((((......))))))(((.(((((......))))).)))...}}|}}}.|||({{((,,,,,.|||({.(((||((((..((((((.......)))))))))))))).)),((((.{{{.((....)}.))).))))(((((({{{{(((,.{,{,,..,.}}}))))))})))))))))))).))))}..),))}})))...)))))))))))).}..))).....)))),...)),))))))).....

Transcripts

ID Sequence Length GC content
NM_001524.1 NCBI
CACAAUUGACAGCCUCAAGGUUCCUGGCUUUUUGAACCACCACAGACAU… 577 nt 0.6846
Summary

This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010]

Forensic Context

A study in rats demonstrated that acute carbon dioxide poisoning induces region-specific mRNA expression changes, with hypocretin (Hcrt) mRNA levels in the frontal cortex showing no significant differences between any experimental CO2 exposure groups and controls [Sato et al. DOI:10.1016/J.Legalmed.2015.07.014].