Basic Information

Symbol
HLA-DMA
RNA class
mRNA
Alias
Major Histocompatibility Complex, Class II, DM Alpha RING6 D6S222E HLA Class II Histocompatibility Antigen, DM Alpha Chain Really Interesting New Gene 6 Protein MHC Class II Antigen DMA DMA Class II Histocompatibility Antigen, M Alpha Chain HLADM
Location (GRCh38)
6:32948613-32969094
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006120.4
Sequence length
1093.0 nt
GC content
0.5306

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-386.00 kcal/mol
Thermodynamic ensemble
Free energy: -407.32 kcal/mol
Frequency: 0.0000
Diversity: 321.28
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((....(((((((.((((((((.(((((.((((((((((.....(((((((((............)))))..)))).....)))))))))((.((((((((.((....)).)))))))).))....((((((.((((..(((((((......((((......))))...((((..(((((....(((((((((((((((...)))))(((...((((((((((((((...))))))))((((.((....(((.(((((........))))).)))......)))))).....((((((...)))))).(((((...((((.((((..(((((..(((((......)))))))...((((((((..(((..(((((.(((((((((((...(((((..((((((((...((.((((......((((..(((((.(((((((....((.((((...))))))..))))))))))))..))))....)))).)).))))))))..)))))....((((.(((((((...((((((.(((....))).))))))...........)).)))))))))((((.(.......).))))(((..((((((.((((((.((((((((......................((((....))))...............(((((...)))))......(((((((((((((..(((((...)))))..((((......(((....))).....))))......)))))))))))).)......))))))))...))))))..))))))..))).........))))))))))).)))))..)))..))))))))..((((((........)))))))))..)))))))))))))))))))...))).((((((((((((((((...((((((...(((....)))..)))))))))))..)))))).)))))..)))))))))))))))........(((((((((......)))))))))....)))).))))))))))))))))).).))))).).))))).))...)))))))))..........................
Thermodynamic Ensemble Prediction
,{.,..(((((((.((((((({.(((((.(((((...||}}}..,(((((((...,.((((.,.((((({....,|,....{((((({.|((.((((((((.((....)).)))))))).))...{(({....||||......,.|.}))))))..,,...,))))}}..,,,})))......))}}}}}.{(((({{,.,,|,},.,}}.})}}|.((((((((({...}))))))))},,(((({..(((.(((((........))))).)))......|{{|||....{((((((,..,)},,}}||||,...((((.(((({{{({((..{{((({{,.,|}}}}},|...((((((((,.(((..(((((.(((((((((((..,(((({,{(({(((((...,{.{(((,...,|||({,.(((((.(((((((....{(,((({...})))}),.))))))))))))..||||,,,,||||,,,.}))))}}},.}})))|||...........|||,.((((((.(((....))).))))))...{((.{{{....))),)))}}}||{|}}}....,},,..,(((..((((((.((((((.((((((((......................((((....))))............,..,{{{|...}}})}....}.,((((((((((((..(((.,.{{(((...}))}}...)},,,,..,,|||.....)))),}....)))))))))))).}......))))))))...))))))..))))))..)))...,.....))))))))))).)))))..))),.)))))))),,{,,{{{..,,,,,,}))))}}}}.,})))))))}}}))}|||||.....,,|||||||,,{,,,,|}...,||||{|||||{,...,,),,,.)))}))}}}}|(((((({.,(((((((((((({.{.,...........(((((((((......))))))))),.,)))))))))))))))))))),))))}))))).}.))))).))...)))))))||....||....................

Transcripts

ID Sequence Length GC content
NM_006120.4 NCBI
GGAGUUGGGGAAGCUGGGUUGGCUGGGUUGGUAGCUCCUACCUACUGUG… 1093 nt 0.5306
Summary

HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that the HLA-DMA was upregulated in monocytes from septic mice compared to sham controls and was selected as a key gene in a machine learning model for sepsis identification, achieving high diagnostic accuracy with an AUROC of 0.904 and 0.924 in independent human test datasets [Li et al. DOI:10.1007/s00011-025-02068-7]. In human sepsis patients, single-cell RNA sequencing analysis found that the HLA-DMA exhibited reduced expression specifically in CHIT1+ neutrophils from non-survivors, associating this downregulation with a pro-inflammatory and immunosuppressive neutrophil phenotype [Li et al. DOI:10.1038/s41598-025-99619-z].