Enables sequence-specific DNA binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within several processes, including embryonic digestive tract morphogenesis; enteric nervous system development; and regulation of T-helper cell differentiation. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]
Forensic Context
A study in human twins demonstrated that the HLX gene, a transcription factor involved in organogenesis, exhibited decreased mRNA and protein levels in placental samples of the smaller twins from growth-discordant dizygotic pairs [Dany Laure Wadji et al. DOI:10.1371/journal.pone.0315549].