Basic Information

Symbol
HRAS
RNA class
mRNA
Alias
HRas Proto-Oncogene, GTPase HRAS1 V-Ha-Ras Harvey Rat Sarcoma Viral Oncogene Homolog Harvey Rat Sarcoma Viral Oncogene Homolog Transforming Protein P21 GTPase HRas P21ras Ras Family Small GTP Binding Protein H-Ras Harvey Rat Sarcoma Viral Oncoprotein Transformation Gene: Oncogene HAMSV GTP- And GDP-Binding Peptide B Ha-Ras1 Proto-Oncoprotein C-Has/Bas P21 Protein P19 H-RasIDX Protein EC 3.6.5.2 C-BAS/HAS C-HA-RAS1 H-RASIDX C-H-RAS H-Ras-1 C-H-Ras Ha-Ras HAMSV RASH1 CTLO
Location (GRCh38)
11:532242-537343
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005343.4
Sequence length
1070.0 nt
GC content
0.6430

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-450.50 kcal/mol
Thermodynamic ensemble
Free energy: -468.98 kcal/mol
Frequency: 0.0000
Diversity: 330.76
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((.(((.(..((((.(((((((..((((((((((..((...(((..((((.......)))).))).))....))))))))))......(((((((((((.((((((((((..((((..(((....)))..)))).((((.((....)).)))).....)))))))).((.(..(((.....)))..)))(((((...)))))......(((...............))))).))))).)))))).))))))).))))..).))).)))(((((((((((((.....((.((..((((((..(((.......(((((...(((((.((((....)))).((((..(((...((((((.(....).)))))).)))..))))....((((.((((.(........).).)))..))))...((((.((((((..((((((..(((((((.((((((((..((((......((((...(((((...))))).(((((((((((..((.(((..(((..(((((.....)))))..)))..)))))...)))))))))))......))))....)))).)))))))).((((..((..(((((((....).))).))).))..))))(((((((.((((.((....(((..(((.......)))))))))))).))))))).(((.(((((....))))))))....(((((....))))))))))))...((((((....).))).)))))))).)))))).))))...((.(((((.(((((..((((((((...(((........)))))))....))).)..)))))))))).))((.(((.((((.((((..((.(((..(((.(((.(..((((.(((((.....)))))(((((((.(((.........))).)))))))(((.(.(((((...))))).).)))........))))...).)))....)))..)))...)).....))))..))))))).))...))))))))))......)))..))))))..)).)).)))).......)))))))))....
Thermodynamic Ensemble Prediction
.(((.(((.(..((((.(((((((..{(((((((((..((..,(((..((((.......)))).))).||....))))))))),...,|.(((((((((((((,(({(((({{{((((((((({{.{{|({{|||{{(({(,{(...,}|,|}}}.,...}}})})})|||....|||,....})).,})})))))).)))))...,.)).))).....},.......)).)).))))).))))))|))))))).))))..}.))).))}(((((((((({(({(({..,.{({{{{{(((,.((,..,.{..((({{...{((((.{(((,.,,}}}|{({((({(((.{{..,,,|},}}}.}})))))}}}.,.||||||,,,}}}}}}})|||||{({((,(({(((,.((({{.....,,.{{{{{(,.{(((((,,({{{(((,((((((((..((((....,.{(((...(((({...})))).,((((((((((..((.(((..(((..(((((.....)))))..)))..)))))...))))))))))}......)))),...)))).)))))))),(({(..,,,}{|||{{{...,).))).})),)}..)}}}(((((((.((((.((....(({,,({{.....,.))),))),)))).))))))).(((.(((((....)))))))),,,.(((((....))))))))}))),.,||||||,,..}.)}).)))))))),)))))).})))},.)))))}))))|((({{.((..,....))))))),,.,||,|}}}|{|,.||||,,..}}.,}))}),,)||.,((,(({(,{{((..((.(((..(((.(({.(..{({,.(((((.....)))))(((((((.(((..{......))).)))))))(((.(.(((((...))))).).)))........))))...).)))....)))..)))...,}}}...))))..)))))))}),.,|)))))))))),,,.,,))),,)})))}}})}|}|,||||.....,})))))))))....

Transcripts

ID Sequence Length GC content
NM_001130442.3 NCBI
AGGCCCGCCCGAGUCUCCGCCGCCCGUGCCCUGCGCCCGCAACCCGAGC… 1178 nt 0.6553
NM_001318054.2 NCBI
AGGCCCGCCCGAGUCUCCGCCGCCCGUGCCCUGCGCCCGCAACCCGAGC… 1152 nt 0.6502
NM_005343.4 NCBI
AGGCCCGCCCGAGUCUCCGCCGCCCGUGCCCUGCGCCCGCAACCCGAGC… 1070 nt 0.6430
NM_176795.5 NCBI
AGGCCCGCCCGAGUCUCCGCCGCCCGUGCCCUGCGCCCGCAACCCGAGC… 1260 nt 0.6611
Summary

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, cognitive disability, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008] CIViC Summary for HRAS Gene

Forensic Context

No relevant information is available at the moment.