Basic Information

Symbol
HSD11B1
RNA class
mRNA
Alias
Hydroxysteroid 11-Beta Dehydrogenase 1 SDR26C1 HSD11 Short Chain Dehydrogenase/Reductase Family 26C Member 1 Corticosteroid 11-Beta-Dehydrogenase Isozyme 1 11-Beta-Hydroxysteroid Dehydrogenase 1 7-Oxosteroid Reductase 11-Beta-HSD1 EC 1.1.1.146 HSD11B HSD11L 11-DH Short Chain Dehydrogenase/Reductase Family 26C, Member 1 Hydroxysteroid (11-Beta) Dehydrogenase 1 EC 1.1.1.201 EC 1.1.1 CORTRD2 HDL
Location (GRCh38)
1:209686178-209734949
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005525.4
Sequence length
1384.0 nt
GC content
0.4386

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-412.40 kcal/mol
Thermodynamic ensemble
Free energy: -438.15 kcal/mol
Frequency: 0.0000
Diversity: 488.89
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..........((((((.((((((...((((.((.....)).))))))))))((((((.((((((((......((((((((((..((.((((((((.((((((((...(((.............(((((...))))).((((..((((((((...((((.((((......(((.(.(((......))).).))).......))))))))...)).....))))))...))))(((((((((((..((((..((((((((((.(((((((((((....((((((((((.....(((.((....))..)))..(((..(((((....)))))..)))(((....((((((((..((((........)))))))..((((.....))))..((((.((((((..(((.((((....)))).))))))).)).))))........)))))...))).....))))))).))))))))....)))))).))).)))))))....))))((((......))))(((((....))))).(((((((((.......)).)))))))..........(((((((((.(((((((....))))))).).)).((((.(((((..(((((((.(((((((((((.(((((((((.......)).)))).....))))))))))))))))).))))...))))).))))...))))))(((((((((...(((...(((((((.(((....(((((((..........(((((((.(((.....))).)))))))(((...)))....(((.(.((((((..............((((.((.....))..)))))))))))))))))))))))))))).)))...)))....)))))))))..)))))))))))((((((...(.(((((...))))).)))))))....)))..)))))))....).)))))...............))).)).)))))))))))))))))).))))))...((((((......)))))).........((((((((.(((((((((....)))).(((.((((.((((..(((......))).))))..)))))))....))))))))))))).....((((((.((...)).)))))).......((((...))))((...)).)))))).((((((.......((((....))))..((((....))))(((((...............)))))(((((((....)))))))((((((((((...)))))))))).((((((..........))))))..........((((.((((........))))...)))).(((((((.....))))))).))))))..........
Thermodynamic Ensemble Prediction
,,,,((,,..(((((({({{(((..,(({({({{{,(((.((((((((((..{.{.....}.,.))))))}}))}.}}}{(((((,,(((,....}|||||}}|.,.,......,,}},,}}}{({{{...})))){{,{{..{|||||,,.....{{,(({(|{|,..((({({(((...{{{|||{{{||}{{.{{{,{||.|((({,,{},||,.,||{{|,,.||||((({{((((({.,{{((({(,((((((,,.,,||||}||||}}..|{((((((((...,,(((,({....}}..}))..(((..(((((....)))))..)))|||,.,,{{{{{{{{.{((((........))))))}..((((.....)))).|((((.((((((..(((.((((....)))).))})))).))}))))....,...})))),.,))).....}})))))}.}},}}))}}..}))))),)||,|}|||},.,||.}}}((((......)))}(((((....))))).((({{{{({{,,,..||}|}}|||||{,{{({,{{((({{{,|||.{((((((....))))))),),}}.((((.(((((.,(((({((.(((((((((((.({(((((((.......)),}))),....,},)))))))))))))).)))},,,))))).))))...,,}}}}||,||||||,..|||..,|||||||.{{{.,.{((((({{..,...,...(((((((.(((.....))).)))))))(((,.,|||,,,,{{,,{.((((({...,,,,,,,,...((((.((.....))..))))}}}))}|})})))}})))|}}|||.,}}.,,|}},.,,),))})))})}))))))))},)|{{{{{,,.{.(((((...))))).})))))),...,,...}}|||,,.,||||||,,,}}))},,....,}}}}||,}}|}}),}}})}))},},,{{{,{(({{,,.((((((......)))))).|.,,.}}}.}}}}}}}.}}},}),}).))})))}.(((.((((.((((..(((......))).))))..))))))).....)))..,)))))))))..{(((({.(|...)).)))))).......{{||..,})))}},,,,},))))})}}}}}||....}})))},.,,,,.{.{,(((({{.,||||(({{({,{({{,,....,|||||,|{{{{(({....}})))}}((((((((({...)))))))))}.{{((((..........))))))..........|}}))}|,|}}..|||||},},,})}}},(((((((.....)))))))...})),.....,},..

Transcripts

ID Sequence Length GC content
NM_001206741.2 NCBI
AGAGAUGAAACAGAAGGAAAGGCAGAGGAGGAGGGAGAGAGAGAGAAGA… 1442 nt 0.4320
NM_005525.4 NCBI
ACAAUUCAGAGGCUGCUGCCUGCUUAGGAGGUUGUAGAAAGCUCUGUAG… 1384 nt 0.4386
NM_181755.3 NCBI
AGAGAUGAAACAGAAGGAAAGGCAGAGGAGGAGGGAGAGAGAGAGAAGA… 1420 nt 0.4310
Summary

The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011]

Forensic Context

A study in human postmortem cerebellar tissue demonstrated that the HSD11B1 mRNA was significantly downregulated in individuals who died from severe frontal cortex traumatic brain injury compared to those who died from natural causes [Schober et al. DOI:10.1007/s00414-014-1129-3].