Basic Information

Symbol
HSD17B10
RNA class
mRNA
Alias
Hydroxysteroid 17-Beta Dehydrogenase 10 SDR5C1 MRPP2 ERAB MHBD 17b-HSD10 HADH2 ABAD CAMR Endoplasmic Reticulum-Associated Amyloid Beta-Peptide-Binding Protein 3-Hydroxy-2-Methylbutyryl-CoA Dehydrogenase 3-Hydroxyacyl-CoA Dehydrogenase Type-2 Mitochondrial Ribonuclease P Protein 2 AB-Binding Alcohol Dehydrogenase Mitochondrial RNase P Subunit 2 MRXS10 SCHAD Hydroxyacyl-Coenzyme A Dehydrogenase, Type II, Hydroxyacyl-Coenzyme A Dehydrogenase, Type II Short Chain Dehydrogenase/Reductase Family 5C, Member 1 3-Alpha-(17-Beta)-Hydroxysteroid Dehydrogenase (NAD(+)) Short Chain Dehydrogenase/Reductase Family 5C Member 1 Short Chain L-3-Hydroxyacyl-CoA Dehydrogenase Type 2 Amyloid-Beta Peptide Binding Alcohol Dehydrogenase Short Chain Type Dehydrogenase/Reductase XH98G2 Short-Chain Type Dehydrogenase/Reductase XH98G2 3alpha(Or 20beta)-Hydroxysteroid Dehydrogenase Type 10 17beta-Hydroxysteroid Dehydrogenase 2-Methyl-3-Hydroxybutyryl-CoA Dehydrogenase Mental Retardation, X-Linked, Syndromic 10 Hydroxysteroid (17-Beta) Dehydrogenase 10 3-Hydroxyacyl-CoA Dehydrogenase Type II 7-Alpha-Hydroxysteroid Dehydrogenase 17-Beta-Estradiol 17-Dehydrogenase Mitochondrial RNase P Protein 2 Type 10 17b-HSD Type II HADH EC 1.1.1.239 EC 1.1.1.178 EC 1.1.1.159 EC 1.1.1.35 EC 1.1.1.62 EC 1.1.1.53 DUPXp11.22 HSD10MD XH98G2 MRX17 MRX31 HCD2
Location (GRCh38)
X:53431258-53434371
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004493.3
Sequence length
954.0 nt
GC content
0.5744

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-363.70 kcal/mol
Thermodynamic ensemble
Free energy: -382.13 kcal/mol
Frequency: 0.0000
Diversity: 342.02
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
........((.(((..((((((((((((((((.(((((((....(((((((.(((((.((..((((....))))(((....))).(((.((((((((((.((((((((((..(((((...)))))..).))))))))))))......(((((((.....))))))).))))))).)))....((((.(....)))))(((....))).(((((((..((((((((((((..(((..((....))..)))..)))......((((...((((((((.(..((.(((((((((((.(((((.......))))))))).)))......)))).))......).)))))))).....))))((((...)))).....((((((((((((.(((((((.((((((.................))).))).))))))).((((....((........))....))))...((((((((((...........(((((.((((((.....((((((..((((((.((((.((((((((....(((...((((((..(((((((((......)))))))))...((((......))))...((...))(((((((....)))))))..((((.((.(((....)))..)).))))..))))))...)))))))))))....)))).))))))....))))))...)))))))))))))))))))))((((....))))(((.....))).)).))))))))))(((((....)))))))))))))).))))))))).))))).)))..)))).(((((........))))).........))))))).))(((..(((((((((.((((((.......))))))...)))))))))..)))..))))))))))...))))..))).))......((((......((((...))))....))))
Thermodynamic Ensemble Prediction
.....({{((,{((..((((((((((((((.,{,,,,,{|{({.{{{,({{(((((((((((((((....}}}{((({.{{}||,(((.(((((((((,{((((((((((..(((((...)))))..),,))))))))))}......(((((((.....))))))).))))))).)))..,..{{,.({,{{|..||{{|||||)||,(((((((..{(((((((((((..(({,{((,...}}.,|||,.}}}.......{((...((((((((.({((.{(((.((((((,{(((((.,....,))))))))).)))...}}}),),.|,......},)))))))),,...}}||((({...})))},.{.(((({((({(,|.|,|||,{{((({{,.,,...,|}...,}}{|||,{{||{||,||,|{(((({{,......{{{{{{.,{{.{{{|...{{{{(((((({{{{.,{{{,.,,|||}|((,(({{{..(,((((({(((({(.{,((,,({{,,{{.,,|{{{,..{{{{||,.{((((((((......)))))))))}},{,||}}}}}})),)..})))}.)),|||||}}}}},}}))))}.||||}||}|||,..,)))..,)),)))}})),}))})}),,}})))))).}}})))}|))}})),.}.)))))),..}}})))))}||||||||||}|{{{{...,})}}|||||,.,.)),},.}}}))))}}}(((({....}))))))))))))).))))||},|{|||||.,,}.,))}},)))|,{{{{{{{{,,{||{{{{.........,,,,)))))}}|||||||||.((((({.....,,|}|}}}...)))))},},}})))..))))))))))..,))))..))),}}})},,.||||,.....,,,|...}},,....))).

Transcripts

ID Sequence Length GC content
NM_001037811.2 NCBI
AUCCCCAUCCCGUGGAGUGGCCGGCGACAAGAUGGCAGCAGCGUGUCGG… 936 nt 0.5748
NM_004493.3 NCBI
AUCCCGUGGAGUGGCCGGCGACAAGAUGGCAGCAGCGUGUCGGAGCGUG… 954 nt 0.5744
Summary

This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Aug 2014]

Forensic Context

A study in aged mice demonstrated that subacute thallium exposure induced sex-specific disruptions in renal energy metabolism, with protein analysis showing a downward trend for the HSD17B10 in the kidneys of aged female mice [Yao et al. DOI:10.1016/J.Fct.2025.115700].