Basic Information

Symbol
HTN1
RNA class
mRNA
Alias
Histatin 1 HIS1 Histidine-Rich Protein 1 Post-PB Protein Histatin-1 Hst1 PPB
Location (GRCh38)
4:70050438-70058848
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002159.4
Sequence length
547.0 nt
GC content
0.3419

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-115.00 kcal/mol
Thermodynamic ensemble
Free energy: -124.06 kcal/mol
Frequency: 0.0000
Diversity: 78.99
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..(((..(((((..((...((((((..((((.(((((.((((.......))))..))))).))))....((((((.(((((((.((..((..(((((....(((.(((((.....)))))..))))))))..))...)).))))))).)))))).....((((.......(((((((.(((..((((((.........((((((...))))))((((.((((..((((.((.....)).))))...)))).))))((((((((((.(((((....((((..(((.(((.(((......)))...))).))).))))....))))).))........((.(((.((((((.(((.......))).)))))).))))).............))))))))..))))))..))).)))))))........))))(((((((.....)))))))......(((........))).)))))).......))..))))).)))...((((((((.(((.((.......)).))).))))))))...........
Thermodynamic Ensemble Prediction
..,{(..(((((..((...((((({..((((.(((((.((((.......))))..))))).))))....((((((.(((((((.((..((..(((((....(((.(((((.....)))))..))))))))..}}.,.)).))))))).)))))).....((((.......(((((({.(((..((((((.........{(((((...)))))}((((.((((,.((((.((.....)).)))),,.}))).))))((((((((((.(((((.,..((((..{((.{((.{((......,})}.,})).},}.))))....))))).))........((.(((.((((((.(((.......))).)))))).))))).............)))))))}..))))))..))).}))))))....,,..}}})(((((((.....)))))))......{{{........}}}.}))))).......))..))))).))|{..((((((((.(((.((.......)).))).))))))))..,,.......

Transcripts

ID Sequence Length GC content
NM_001368990.1 NCBI
AUCUCUUGAGACUUCACUUCAGCUUCACUGACUUCUUGACUCUCCUCUU… 526 nt 0.3384
NM_002159.4 NCBI
AUCUCUUGAGACUUCACUUCAGCUUCACUGACUUCUUGACUCUCCUCUU… 547 nt 0.3419
Summary

This gene encodes a member of the histatin family of small, histidine-rich, cationic proteins. They function as antimicrobial peptides and are important components of the innate immune system. Histatins are found in saliva and exhibit antibacterial, antifungal activities and function in wound healing. [provided by RefSeq, Aug 2014]

Forensic Context

A study in humans demonstrated that HTN1, a saliva-specific mRNA, was included in a next-generation sequencing multiplex panel for body fluid identification and was expressed in buccal swabs but not in peripheral blood samples [Miao et al. DOI:10.1016/j.fsigen.2025.103229]. A study in humans demonstrated that HTN1 is detectable in saliva and, to a significantly lesser extent, in some semen RNA isolates, but is not found in blood, menstrual blood, or vaginal secretions [Juusola & Ballantyne DOI:10.1016/j.forsciint.2005.02.020].