Basic Information

Symbol
ID1
RNA class
mRNA
Alias
Inhibitor Of DNA Binding 1 BHLHb24 DNA-Binding Protein Inhibitor ID-1 Inhibitor Of Differentiation 1 Inhibitor Of DNA Binding 1, Dominant Negative Helix-Loop-Helix Protein Class B Basic Helix-Loop-Helix Protein 24 DJ857M17.1.2 ID DJ857M17.1.2 (Inhibitor Of DNA Binding 1, Dominant Negative Helix-Loop-Helix Protein) Inhibitor Of DNA Binding 1, HLH Protein BHLHB24
Location (GRCh38)
20:31573014-31606515
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002165.4
Sequence length
983.0 nt
GC content
0.5788

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-391.10 kcal/mol
Thermodynamic ensemble
Free energy: -407.42 kcal/mol
Frequency: 0.0000
Diversity: 303.97
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
....(((..(((.(((.(((((((.(((((.....((((((((.((((.........((((((((((((.......((..(((((.((.........((((....((((((((((((((....((...(((.(((.((((((((.(((((..((((.....))))..).))))...((((((((((((((((((.(((..(((((....)))))..))))))))))))).))))))))))))).))).))))))...)))))))..)))))..((((((((.(....).))))))))..)))))))))))))))..))...(((((...((..((((.((.......)).))))..))...))))).))))))))))))..(((((((..(((.((..........))))).....)))))))........)))))))))))))))))((((.((((((.(.((((((((((((((((...((((((((.((.(((..((((.......)))).))).))..((.((((.(((((.((........)).))))).)))).)))))).))))...)))....)))))))))).)))).))).))).))))(((((((((.....((((..((.(((....)))))..)))).((((((.(((...((..........))))))))))).....((((((((..((((.....((((.((.(...).)).))))....)).))..)))))))))))))).)))...((((..((((......)))).))))((((((....))))))..(((...(((((((((((((........))))))))))))).)))..((((((.(((((((....)))))))..........(((((((...)))))))..))))))..(((..((((((...)))))).))).))))))).)))..((((((....))))))......)))..)))
Thermodynamic Ensemble Prediction
....(((,.,{,.,{{.({,((({,{{,,{.....((({{(((.{{{{...,.....,.,{{{{({(((,.....,({,{(((((,{({{....,..{{{{|...{(((((((((((((,,..((...{((((((.((((((((.(((((..((((.....))))..).))))...(((((((((((((((((({(((..(((((....)))))))))})))))))))).))))))))))))).))).))))})}.,)}}))))..)))))..((((((((.(....).))))))))..}}})}}}}.,|||}|..,|,||.{{{{{,.((.{(((({((.....,,}|{||||{.||||.|||||.}.,,||}||{{{{{({({(((,,(({.{{,,,,...,|.||}}}.,,,,||,}}})}})),,||})},}))))))))))},(((((((((((.(.((((((((((((((((...((((((((.{(.(((..((((.......)))).))).))..((.((((.(((((.((........)).))))).)))).)))))),,)))...}))}...)))))))))).)))).))).))).))))|,,{{{{|{...,,||||}.{|.|||,,,})))},..,)))}|{|||||.||}}.|||,}.....,.|||,,,|||}}.....,|||||||..,{||..}||||||,|}}},,}))))}))))},})))})|{{||||},,,}))))),)||,,.((((..((((......)))).))))((((((....)))))).|{{{,..(((((((((((((.,......))))))))))))).}))},,,||{|,(((((((....))))))).......,,,(({{{{,...)))))}}..}}||,|{.(((..((((((...)))))).))).))}))}|,|||,.{(((((....)))))).,,...))),,)}}

Transcripts

ID Sequence Length GC content
NM_002165.4 NCBI
AUUCCACGUUCUUAACUGUUCCAUUUUCCGUAUCUGCUUCGGGCUUCCA… 983 nt 0.5788
NM_181353.3 NCBI
AUUCCACGUUCUUAACUGUUCCAUUUUCCGUAUCUGCUUCGGGCUUCCA… 1222 nt 0.5876
Summary

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human menstrual blood-derived mesenchymal stem cells (MenSCs) demonstrated that the ID1 gene is overexpressed in cells from women with endometriosis and plays an important role in inflammation associated with the disease, interacting with TNFA and hypoxia signaling pathways [Penariol et al. DOI:10.3390/ijms231911515].