Basic Information

Symbol
ANAPC13
RNA class
mRNA
Alias
Anaphase Promoting Complex Subunit 13 APC13 SWM1 Anaphase-Promoting Complex Subunit 13 Cyclosome Subunit 13 DKFZP566D193
Location (GRCh38)
3:134477704-134486716
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_015391.4
Sequence length
1170.0 nt
GC content
0.3906

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-272.30 kcal/mol
Thermodynamic ensemble
Free energy: -296.87 kcal/mol
Frequency: 0.0000
Diversity: 362.44
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((((((((((.....((((((..((((((.(.(((((.....))))).).))).......((.(((.((((((((...((.((((((.(((.(.(((...))).).))).)))........((((..((........))..))))......)))))...)))))))))))..)).(((((.....((((.((.((...((..((((((......((.....)).....))))))......))....)).)).)))).....))))))))))))))......))))))).)))))).....(((((((..((((.((((((((((((((((((((..((((((................)))))).((((((...........))))))((((((.((((((((((((((...((.(((...))).))...))))))))))....((((((....))))))...)))).)))))).................((((......)))).)))).))))))..(((((..((((.....(((((((...(((((.(((((((......).))))(((((((((((.............((((........))))))))).))))))..)).)))))...))))))).....((((((((((..((((((.((((......(((((((.............)))))))((((.(.((.((.....)))).).))))..(.(((((....))))).)))))))))))..))))).)))))..))))..)))))...............((((.((((..(((((.........)))))..)))).))))..(((((...(((((((.....(((((..((((.(((((..((((((..((((((((((......))))))...))))....)))))).))))))))))))))(((........))).....((((......)))))))))))..))))).))))))))))))))..)))))))..............((((..((((....((((..((((((.(((((.(((.......((((........))))(((.(((.(((........)))...))).))).)))..)))))))))))..))))..))))...)))).........
Thermodynamic Ensemble Prediction
{((((((((((((.,,..{(((((..(((((({({((({,..}}})),||,|,|||.,....,{{,((({{(((((((,.,((.(((,,{,{{{,{,{{|,,,|||{|,,||{{{((,{.....,.}}}})|,||,..,.|||.,||},,,...}}}}}...}}}}})))))}..||,{,,,,.....,{||,||,||,,,,{..{(((({......{{.....,,..,,,)}}}}},|,..,,,,...}}.}},}}}},,,..}}}}}|,,}}}}})|,....))))))),}))))),,,..{{({{{(|,{(((,|{{({({{{{((((((((((..((((((..,..,....,..,..)))))){((((((...........))))))},,{{{.{{{{(((((((((({{,,{.(({...)))..)}},))))))))))....((((((....))))))...||||,|,}}))}})}.,|,.....,...((((......)))),)))).}})))|,,{{,{|,||||......{((((((...(((((.{{.,{{{,,,|..,.}}}}(((((((((({............,((((........))))))))).))))))..}}.)))))...))))))|.....((((((((((..((((((.((({......(((((((.............)))))))((((,(,{(,({.....)))),,.)))).,(.(((((....))))).}))))))))))..))))).))))).,{{{|{{{{{.((({{{{{{.,,.{{{(||........|||||,.},,,},})))))|,||...,,,,}}|||,,...{(({(({,,,.,|||{{..((((((((((..((((((..((((((((((......)))))),..))))....)))))).))))))))),}}},.....,,,...,)),,,..{{{{....,{||||...,)))}}}|||,.|||}}}}}}}}}})..}})))})},},,...,,....||||...,||,,,,((((..((((((.(((((.{{{,,,....((((........)))).,{|||{,|||...,.,},)),...}}}...)}))}..)))))))))))..)))).....,...}}},,,,......

Transcripts

ID Sequence Length GC content
NM_001242374.1 NCBI
GCAGACACGUGAUGCGGGGGAGGGGGGGGGGGCGUGGCAGGAGCAAGCG… 1859 nt 0.4470
NM_001242375.1 NCBI
UGGCAGGAGCAAGCGUCUGCCGCGGUGGCCGGGUGCCGGUAAGGGUUUC… 1444 nt 0.4238
NM_015391.4 NCBI
AGGAGCAAGCGUCUGCCGCGGUGGCCGGGUGCCGAUUUGACAAGAUCAA… 1170 nt 0.3906
Summary

This gene encodes a component of the anaphase promoting complex, a large ubiquitin-protein ligase that controls cell cycle progression by regulating the degradation of cell cycle regulators such as B-type cyclins. The encoded protein is evolutionarily conserved and is required for the integrity and ubiquitin ligase activity of the anaphase promoting complex. Pseudogenes and splice variants have been found for this gene; however, the biological validity of some of the splice variants has not been determined. [provided by RefSeq, Nov 2008]

Forensic Context

A study in mice demonstrated that chronic methamphetamine administration significantly dysregulated the ANAPC13 in microglia, as part of a broader disruption of the ubiquitin-mediated proteolysis pathway [Oladapo et al. DOI:10.3390/Ijms26020649].