Basic Information

Symbol
ID2
RNA class
mRNA
Alias
Inhibitor Of DNA Binding 2 BHLHb26 Inhibitor Of Differentiation 2 GIG8 Inhibitor Of DNA Binding 2, Dominant Negative Helix-Loop-Helix Protein Class B Basic Helix-Loop-Helix Protein 26 DNA-Binding Protein Inhibitor ID-2 Cell Growth-Inhibiting Gene 8 Inhibitor Of DNA Binding 2, HLH Protein DNA-Binding Protein Inhibitor ID2 Helix-Loop-Helix Protein ID2 BHLHB26 ID2A ID2H
Location (GRCh38)
2:8678845-8684461
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002166.5
Sequence length
1299.0 nt
GC content
0.4249

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-352.10 kcal/mol
Thermodynamic ensemble
Free energy: -378.46 kcal/mol
Frequency: 0.0000
Diversity: 323.20
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...((((((..(((...((((...)))).))).))))))(((((((((((((((.((((.(((...(((((.((((((((.....((((........((((((((...((.((((....)))))).))))))))((((.((((........)))).))))((((((((((((.....))))).))........)))))..))))...(((((.((..........................)).))))).)))))))))))))))).................((((((((....((..(((.(((((...(((...((.....))...)))))))))))..))..((.((.(((.........))).))))))).)))))...(((((((......)).)).))))))).)))))))).))...((((....(((..((((...(((((....)))))...))))..)))....))))....((((....)))).((((((((((.((..(((((.((((((((.((((.((((.......((.((((((............(((.(((((((((.......(((((.....)))))........((((((.((..(.....)..)).)))))).((((((..................))))))....(((((((.((.((((((...)))))).))..)).))))).)))))).))).)))...((((((.(((((((((...(((.......)))....))))))))).))))))(((((((((((...)))))((((....))))....((((((((..((((.(((......((..((((((((((....))))))))))..))....((....))...(((((((((((.((((.....))))..((((((((((((.....)))))))).))))...)))))))))))...(((((((((....)))))))))....))).))))..))))))))(((((......)))))........))))))((((((((....))))))))........)))))).)).............(((((((((((...))))))))))).((((((...((...(((((.....)))))....))..)))))).)))).)))).)))).))))...)))))...))))))))))))..((((((((((((((((......(((((..............))))).....))))))............))))))))))...)))))...............
Thermodynamic Ensemble Prediction
...((((((..(((...((((...)))).))).))))))((((.((((((((((.((((.({{...(((({,((((((((.....((((,,,,....((((((((...((.((((....)))))).))))))))((((.((((........)))).)))){(((((((((((.....))))).))........)))))..))}),}.{((((.{{..................}|......}}.))))}.)))))))))))))))).,,,...,,.....{..{((({(((.{{{,,..}}},|||,{...{|{,.,{{,....}),,}))}})))}),},|||||((,{,.{{{.........})}..|{{{|,.||.,,...||,,|}|},.,,.})}))}))))))).)))))))).))...((((....(((..((((.,.(((((....)))))...))))..)))....))))....((((....)))).{{((((((((.((..(((((,((((((({.((((.((((.......,{.{(((((...................,{,,{{{{.....(((((,....}}}}}..,|||..((((((.{{,,({{{,.|..}}.}}}}}}.|{{({{,...............,,}}||}},,,..,,,(({{{{{(((,,{,{.||||||......}})))))}.,))))}}))},}}...((((((.(((((((((,,.(((.......))).,},))))))))).)))))).....,(((({...}))))|(((....))),....{(((((((..((((.{{,......((..((((((((((....))))))))))..))..,,({....}}.,.(((((((((((.(({{.....}||,..{(((((((((((.....)))))))).)))}...))))))))))).|,(((((((({....)))))))))..,.))).))))..)))))))}(((((......))))),.,,}}}}.,|}}}((((((((....)))))))),,......)})}}|.||,,........}},(((((((((({...})))))))))).{(({{{........{{{{|.....}}}}}.....,,.)))))).)))).)))).}))).)))).,.)))))...))))))))))}|{{(((,,,((((.,.((((((({,({,{{........,,,,..|||}}.....,}},,},}}}}}},}},}))))))).,.}}}),,,),}}}},...))))..

Transcripts

ID Sequence Length GC content
NM_002166.5 NCBI
AUUCUGAGCCGAGCCCGGUGCCAAGCGCAGCUAGCUCAGCAGGCGGCAG… 1299 nt 0.4249
Summary

The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]

Forensic Context

A study in humans demonstrated that higher mRNA levels of the ID2 in peripheral blood mononuclear cells (PBMCs) from female bipolar disorder patients were significantly associated with lithium non-response, alcohol dependence, and suicide attempts [Voinsky et al. DOI:10.1002/Ddr.21598]. Specifically, expression was higher in lithium non-responders versus responders, in patients with alcohol dependence records versus those without and versus controls, and in patients with suicide attempt records versus controls.