Basic Information

Symbol
IFI27
RNA class
mRNA
Alias
Interferon Alpha Inducible Protein 27 P27 FAM14D ISG12 Interferon Alpha-Inducible Protein 27, Mitochondrial Interferon Alpha-Induced 11.5 KDa Protein Interferon-Stimulated Gene 12a Protein ISG12(A) ISG12A 2310061N23Rik
Location (GRCh38)
14:94104836-94116700
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001130080.3
Sequence length
652.0 nt
GC content
0.5537

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-246.60 kcal/mol
Thermodynamic ensemble
Free energy: -257.98 kcal/mol
Frequency: 0.0000
Diversity: 211.24
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((((((....(((.(((..((((((....))))))..))).)))....((((((..(((((((((((((..((.((((((............(((((((((.......))((((((((......)))..))))).(((.((((.....))))...)))((((((...))))))..)))))))..((((((((((((((...(((((((((((.((((.((.((((....)))).)).)))).)))))).)).)))...(((((((((((...)))))))))))...)))))))))))....)))..)))))).))..)))))).(((((((.((((((.(((.....((((((((((((((((.(((.((((....)))).))).))))))).....((((((..((((((..((....))....)).))))..)))))).)))))))))....))).)))))).)))))))(((.((((((.((...((.((((..........)))).)))))))))).)))...((((...(((.....))).))))))))))).)))))).....(((((((........)))))))............((((.....(((...))).....)))).....))))...))))....
Thermodynamic Ensemble Prediction
,{{{((((...,((,.(((..((((((,,,,||||}|..}||,|{{{...,||||||.{{|||{{{|{{{|,|||,||{,...,}}},}},,},.((((((((......,),((((((((......))),.})))){(((..,....}..))))....,)}||||...,,(({(((((((({,..,((,(((((((((((...(((((((((((.((((.({.((((....)))).}).)))).)))))).)).)))...(((((((((((...)))))))))))...)))))))))))....|||{.,{{|||,,,.,|||||..{({({(({(((,(({(((,{,,.((,,,||{|||||{{|,|||.||||}|,||,,}.))),}}}}}||{{{{.{{(((({{.,,{(({,|{{||{|{.,|{|,..}}},,}})}))}))))},})),..,))),))}}))}})))}}}{||,||{{{{.{{.,,||,|(((..,,..,.,,)})).),}}}}}})).))).,)))))..})))..,)))))))))))))))))},})))}},,..(((((((........)))))))............{(((,....,{|,,,)}}.....}},,.....))))...}))}....

Transcripts

ID Sequence Length GC content
NM_001130080.3 NCBI
AACACAUCCAAGCUUAAGACGGUGAGGUCAGCUUCACAUUCUCAGGAAC… 652 nt 0.5537
NM_001288952.2 NCBI
AACACAUCCAAGCUUAAGACGGUGAGGUCAGCUUCACAUUCUCAGGAAC… 705 nt 0.5589
NM_001288956.2 NCBI
AACACAUCCAAGCUUAAGACGGUGAGGUCAGCUUCACAUUCUCAGGAAC… 618 nt 0.5583
NM_001288959.2 NCBI
AACACAUCCAAGCUUAAGACGGUGAGGUCAGCUUCACAUUCUCAGGAAC… 503 nt 0.5467
NM_001366993.1 NCBI
GGCAGGAGCUACCCUUCCCGUGGCCCCGGACCUUGGGUGGGCUGUGGGC… 720 nt 0.5833
NM_001366994.1 NCBI
AACACAUCCAAGCUUAAGACGGUGAGGCCACGGAAUUAACCCGAGCAGG… 582 nt 0.5636
Summary

Enables several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; identical protein binding activity; and lamin binding activity. Involved in several processes, including defense response to other organism; protein K48-linked ubiquitination; and pyroptotic inflammatory response. Acts upstream of or within negative regulation of transcription by RNA polymerase II and regulation of protein export from nucleus. Located in mitochondrial membrane and nuclear inner membrane. Is active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]

Forensic Context

A study in humans demonstrated that the IFI27 is part of a 38-gene transcriptomic signature of obesity, with a positive coefficient of 0.0458, and this signature correlated strongly with body mass index (R = 0.63, p = 2.87 × 10−71) and fat mass in subcutaneous adipose tissue [Francesc Font-Clos et al. DOI:10.1088/1361-6579/aab85a].