Basic Information

Symbol
IFI30
RNA class
mRNA
Alias
IFI30 Lysosomal Thiol Reductase GILT IP30 Gamma-Interferon-Inducible Lysosomal Thiol Reductase Legumaturain IFI-30 IP-30 Interferon Gamma-Inducible Protein 30 Preproprotein Gamma-Interferon-Inducible Protein IP-30 MGC32056 Interferon, Gamma-Inducible Protein 30 Interferon Gamma Inducible Protein 30 IFI30, Lysosomal Thiol Reductase EC 1.8.-.-
Location (GRCh38)
19:18173162-18178121
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Wound age identification Mechanical injury analysis Individual identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_006332.5
Sequence length
988.0 nt
GC content
0.5557

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-338.00 kcal/mol
Thermodynamic ensemble
Free energy: -356.66 kcal/mol
Frequency: 0.0000
Diversity: 269.67
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((..((.........))..)))).(((((......))))).......(((......((((((((.((((((((((.(((......)))))))))))))(((((.......)))))..(((((.((((((((((((....((((.((.((.....))....((((.........)))).)).)))))))))))))))).)))))...(((..(((..(((......)))..)))))).....)))))))).(((((((..(((((...)))))))))..........)))(.((((((((((.(........(((....((((.(((((.((....))...))).........(((((((.((((((.((.....(((((((..(((((((((((((.((..((((((((((((....))))...))))))))...(.(.((.((((((.(((.((((((((((((((((.((((..((((((..(((.((((((((....)))....))))))))..))))))..(((....)))((((....))))....)))).))...)))))))((((..(((((.((((.....)))).)))...((((((.((.((.((((((..............)))))).))))))))))..........(((...)))..(((((..(((((((.(((.(((.((((.(((........).)).)))).))).))).))..)))))..))))).......))))))))))))).))).)))))).)).).)..(.(((((((......))))))).).((((.(((.((...)).))))))))))))))))))...))))....)).))))))).)))))).)).))))).....((((((.....))))))))))))....)))........).)))))))))).).....((.(((.......))).))((((.((....)).))))...)))
Thermodynamic Ensemble Prediction
((((..(((,({((((,.{{(,(((((((.{(((((({((((((((.,...(((((((((((((((.((((((((((.(((......)))))))))))))(((((.,.....}))))..(((((.((((((((((({...{((((.((.({.....,,..,.((((.........))))}})})))))))))))))))).)))))...(((,.{({..{{|,.....}}}..}))))).....))))))))....((((.{(((,,...,))))))))...{{{{((,,,,|}}})),|||}({{...}}}..,|,|,,...,|||{,,...}}....)}}})))))))....)..)))))).))}))).)}),,..)),})))).)).}.,}}}|{||},..||||,,||||||}..}))))}}.}||,||||...((((((((((.{,.,(({(((({(,{,,,,|||,.||,|}}||,|||.,,((.{,(((((((..{{||{{{.|,.,||,|{{{{({{{..{{{..,,)))|||{....)}||,,..,,}},))},}}}}.|||(,(...((((({((,,...}}))),})),..}.}}}||.}|.)|}||,|||}}}},,,..,....||{{|.{|{{{,,(((((.{{((({..(((...}))..(((((..(((((((.(((.(((.((((.(((........).)).)))).))).))).))..)))))..)))))..,,...{((((....)))))},},}||,,..,}))})){{.(((((((......)))))))||.((((,{((.((...)).))))))),)).......,||...,,))}})..))))).)))).........{(((,...(((({((.,,,.}}}}}}}.}))),,.,,.....,,,,...))))).))))).}}}),)).,(((({....))))).{{{{.{{....}}.}}}}......

Transcripts

ID Sequence Length GC content
NM_006332.5 NCBI
GCAGUCGCCACACCUUUGCCCCUGCUGCGAUGACCCUGUCGCCACUUCU… 988 nt 0.5557
Summary

The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing. [provided by RefSeq, Jul 2008]

Forensic Context

A study in rats and pigs demonstrated that the IFI30 exhibited analogous time-dependent expression patterns in skeletal muscle following contusion injury and was validated as part of a key gene set enabling a cross-species prediction framework for injury time inference, achieving 81.1% accuracy on an independent porcine test set [Wang et al. DOI:10.1007/s00414-026-03727-y]. In human subcutaneous adipose tissue from BMI-discordant monozygotic twins, the IFI30 was upregulated in heavier co-twins and associated with cytokine-mediated signaling and immune system processes, linking its expression to inflammatory pathways in obesity [Muniandy et al. DOI:10.1038/ijo.2017.95]. A study in mice demonstrated that the IFI30 is upregulated in skeletal muscle following both local and distant burn injury, showing increased expression at 1 and 3 days post-local burn and at 1 and 2 days post-distant burn [Padfield et al. DOI:10.01.ta.0000230567.56797.6c]. In a separate mouse model of mild traumatic brain injury, the IFI30 transcript was found to be upregulated 4.2-fold in the injured ipsilateral neocortex three days post-injury, associated with antigen processing and presentation [Israelsson et al. DOI:10.1089/neu.2008.0676].