Basic Information

Symbol
IFI6
RNA class
mRNA
Alias
Interferon Alpha Inducible Protein 6 IFI-6-16 IFI616 FAM14C 6-16 G1P3 Interferon Alpha-Inducible Protein 6 Interferon-Induced Protein 6-16 Interferon, Alpha-Inducible Protein (Clone IFI-6-16) Interferon, Alpha-Inducible Protein Clone IFI-6-16 Ifi-6-16
Location (GRCh38)
1:27666064-27672212
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden unexpected death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002038.4
Sequence length
812.0 nt
GC content
0.5616

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-313.90 kcal/mol
Thermodynamic ensemble
Free energy: -327.38 kcal/mol
Frequency: 0.0000
Diversity: 207.66
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((.((...(((((((..........((.(((((((((..(((((.......)))))..)))......(((....))))))))).)))))))))(((.......))).(((((((....)))))))...((((((((((((.(((((((((...))))))).)).))))))).......)))))..((((((...((((((.((.((.(((((((((..((((.(((...))).))))....(((.....)))(((((((((((((((((((((((((......)))))).)))....))))))....)))))))))).((((.(((......))).)))).((.....))(((.((((((((((.(((((.(((((((((.(((((((...(((.(.......).))).))))))).))))).........)))).))))).))))).))))).)))....((((((((.....(((((((.((.(((((........)))))))...))))))).((((.((((((((((((.....)))))))....................................((((((((((...(((((....((...(((((((((((((((((((((((.(....).))..))))).))))))........))).))))))))))))))....))))))))))....))))).))))......((....))))).)))))))))))))).)).))))))))....)))))).............(((....))))).)))))...............
Thermodynamic Ensemble Prediction
((((..{,{({((((({{........,,|{.{((((((((..(((((.......}}}}).,}||,.....(((....))))))))).}}||||}}}||,.....|||||{(((((((....)))))))}}.,}}}((((((((.(,(((((((...))))))).)}.)))))))).,.....|,|,,,((((((...(((({|.{{.((.(((((((((..((((.(((...))).)))).,,{((({{{{,,|,(((((((((((((((((((((((((......))))))},))....))))))....)))))))))).,{(({(,{|.|,||}|}|}}}|{(({...,||(((.((((((((((.(((((.(((((((((.(((((((...(((.(......,).))).))))))).)))}}.......,,)))).))))).))))).))))).))).,,.,,.{{{{{.....|||((((,{{.(((({.,....,.)))))}}...))))))).{{{{,(({(((((((((.....))))))).,,.||},............................{(((((((((...(((((....((...(((((((((((((((((((((((.{....}.)),.})))).))))))}.......,)),})))))))))))))....)))))))))}....)))}}.))))......(({{.{|,,,.))))))))))))))).)).)}}})))}..,,|}}}}}..........,,,.||}|..}}}}}.,,,,}}}},,...}.},,,.

Transcripts

ID Sequence Length GC content
NM_002038.4 NCBI
GUUUACUCGCUGCUGUGCCCAUCUAUCAGCAGGCUCCGGGCUGAAGAUU… 812 nt 0.5616
NM_022872.3 NCBI
GUUUACUCGCUGCUGUGCCCAUCUAUCAGCAGGCUCCGGGCUGAAGAUU… 824 nt 0.5619
NM_022873.3 NCBI
GUUUACUCGCUGCUGUGCCCAUCUAUCAGCAGGCUCCGGGCUGAAGAUU… 836 nt 0.5610
Summary

This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human infants identified elevated cerebrospinal fluid neopterin, a biomarker of neuroinflammation, in a subset of sudden infant death syndrome (SIDS) cases, with single-nucleus RNA sequencing of the medulla from an HPeV3-positive case revealing significantly higher transcript abundance for the interferon-induced gene IFI6 within serotonergic neurons compared to noninflammatory SIDS controls [Ramachandran et al. DOI:10.1001/jamaneurol.2023.5387].