Basic Information

Symbol
IGFBP2
RNA class
mRNA
Alias
Insulin Like Growth Factor Binding Protein 2 IBP2 Insulin-Like Growth Factor Binding Protein 2, 36kDa Insulin-Like Growth Factor-Binding Protein 2 IGF-Binding Protein 2 Insulin-Like Growth Factor Binding Protein 2 (36kD) Insulin-Like Growth Factor Binding Protein 2 IGF-BP53 IGFBP-2 IBP-2 BP2
Location (GRCh38)
2:216632828-216664441
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000597.3
Sequence length
1414.0 nt
GC content
0.6740

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-689.10 kcal/mol
Thermodynamic ensemble
Free energy: -713.71 kcal/mol
Frequency: 0.0000
Diversity: 533.58
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.........((((.(.(((.(((...((.((((...)))))).))).))).)))))((...(((.(((.(((((((((.(((.((((.((.((..((((.(((((.(((((....(((((((.(((((((((((((.(((((((((((((((((((.(((((.((....)).)).....))))).))))))))))))))))))))).)))))).)))))....)))))((((((((((......(((((.((..((.((.(((((((((((((((..(((((((((......))))).)))).))).))).)).))))))).))...))..)).)))))..)))).).))))).))))))))))..))))..)))).))))))).)))))).))).))))))...((.((((((((((((..((((((((((((((......((....))((((((.((((.(((....((((((..(((((((.(....).)))))))..))))))))).((((......)))).)))).))))))((((((...(((..(((.(((......(((..((((((((((((((((.(((((((..((......))..)))))..(((((((.....(((.(((((.((..((((.((..(((((((....((((.((..(((.....)))....)).)).)).....)).))))).)).))))..((((((...(((.(..(((((.((.....)).)))))..).)))..)))))))).))))).))))))))))..(((((.(((...))).)))))....)).))))))))).).)))))).(((((.((((((.....(((((...)))))..)))))).)))))....))).......))).)))))).))))))....)))))))....)))))))..)..))))))))))).))(((((.(((((.(((((.......(((......))).(((..(((((.......)))))..)))(((((.((..((.(((......))).))...)).))))).))))).))))))))))((((((((.........(((((((((((((((((((((((((((...((..((((((.................)))))).))..)))))).))))))))).((.((((((((.....................))))))))...)).)))))).))).))).((((((((((((......((((((((.(....(((((((((.(((((((((..........))))))).)).))).))))))...).))))))))...))).)))))))))(((...((((((....))))))...)))))))))))((((((........))))))..)).........
Thermodynamic Ensemble Prediction
..,,..,..((({.({(((.{{||||,{||||{{{,||||||.|||.|||{|||}|{(((((((.{(({((((({(({{(((.({{({((,(({,{..|,||||{.||{|{,,.,{||||||.{{{((((((((((.(((((((((((((((((((.(((,(.(,.{{.,,.))....,))))).))))))))))))))))))))).)))))).|||||,|,,||||}{{{(((((((....,,{{((({((,{((,((.(((((((((((((((.,,((((((((.,..,,)))))||))},|})|}||,}|.|}}}||}.||...)),,}}.))|}||,})}}.}||}|||.||}}||}}}}}}))))}}))))}))))}}}.))))))}})),))))))|,,,,.{{{{||||||||},|(((((({((((((....,(({....))|({{{{.{{{|||||,.,,{(({({,.{{{{||{|,..,}).|||}}}}..})})))|||.((((......)))).}})),)))})){(((((,..,{,..{||.{{{.,,.|,{|,,,|{,{{{|{{(((({{{.|||{||||,||,,,}}.}}..,,}}},}||||||{}.,,,||{,{{|||,||..((((.{{..{{{||||.{{.{{{(,{((((({.,(({{{{.|{..||||,||,.,||||.|||}}.},,))))..((((((...(((.(..(((((.((.....)).)))))..).)))..))))))}),))))),)))}}))}))..{{|||,|||}.,))).))))|,,{.}}.}))))}})}.},}|||||{(((((.({((((,.,,,(((({,,,|}}||,,||||||.|}}||{...,,|.|{,,..}}}.||||||.}}}}},...,)))}))}...,)))})})..,},)}})})))))),))|((((,(({((.,{(((.....,}||,,|.||.})),|||.}||||{..},,,,)))))).|}}|{{{{,||.,{{|{|{,.....|}|,}}.,,},.))))},))))).)))))))}}}{{{{{{{|..,.,,}}.((((((((((({{((({|((((,(((({{{(({(((((((.................)))))).|,..)))))).)))|)||||.||.{(((((((...,,{,....,,........)))))))}...))))))))).))).))).((((((((((((......((((((((.(....(((((((((.(((((((((.{,,.....,)))))))))),))),})))))...).))))))))...)))))))))))))(((...((((((....))))))...))))))))}}|{{{{{,,........,.,}}..}}.........

Transcripts

ID Sequence Length GC content
NM_000597.3 NCBI
GAGGAAGAAGCGGAGGAGGCGGCUCCCGCGCUCGCAGGGCCGUGCCACC… 1414 nt 0.6740
NM_001313990.2 NCBI
GAUUCAGAUCCUCUCUGCCUCCUUUGGCUGGACGUGCCUCAGCCAGAGU… 1048 nt 0.5859
NM_001313992.2 NCBI
CAGGUUUGGAAAACUGCAAUAGUCACUAAGACCAUUCGGGGCUGUUUGG… 1316 nt 0.5904
NM_001313993.2 NCBI
CAGGUUUGGAAAACUGCAAUAGUCACUAAGACCAUUCGGGGCUGUUUGG… 1055 nt 0.5848
Summary

The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]

Forensic Context

A study in mice demonstrated that perinatal lead exposure altered adult hippocampal cell composition, increasing oligodendrocyte proportion by 12.4% and causing differential gene expression in specific cell clusters [Bakulski et al. DOI:10.1093/toxsci/kfaa069]. In the context of traumatic brain injury, research in animal models shows that the IGFBP2 mRNA is upregulated close to the injury site, with this increase being glutamate-dependent and potentially involved in edema formation [Mangiola et al. DOI:10.1155/2015/736104]. A study in mice demonstrated that the IGFBP2 was specifically down-regulated following Kupffer cell-specific exposure to α-particle radiation, as identified through oligonucleotide microarray analysis of liver tissue [Roudkenar et al. DOI:10.1269/jrr.07078].