Basic Information

Symbol
IGHA1
RNA class
mRNA
Alias
Immunoglobulin Heavy Constant Alpha 1 AL928768.3 Immunoglobulin Heavy Chain Constant Region Alpha 1 Ig Alpha-1 Chain C Region BUR Ig Alpha-1 Chain C Region TRO Ig Alpha-1 Chain C Region Immunoglobulin Alpha 1 IgA1
Location (GRCh38)
14:105703995-105708665
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
-
Sequence length
- nt
GC content
-
Summary

Contributes to immunoglobulin receptor binding activity. Involved in glomerular filtration and positive regulation of respiratory burst. Located in extracellular space. Part of monomeric IgA immunoglobulin complex and secretory dimeric IgA immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans demonstrated that the IGHA1 was increased in expression within B2 and B3 B cell subgroups in peripheral blood mononuclear cells from an irradiated patient, where it was associated with inflammatory and immune response pathways [Yan et al. DOI:10.3892/etm.2025.12846]. Separate research in humans identified the IGHA1 as part of the principal component 2 of spatially variable genes, showing higher enrichment in the cavernosal artery region of the corpus cavernosum [Yin et al. DOI:10.1016/j.celrep.2024.114760].