Basic Information

Symbol
IGKC
RNA class
mRNA
Alias
Immunoglobulin Kappa Constant HCAK1 Immunoglobulin Kappa (Invariant Region) Immunoglobulin Kappa Light Chain (VJ) Immunoglobulin Kappa Constant Region Ig Kappa Chain C Region CUM Ig Kappa Chain C Region ROY Ig Kappa Chain C Region AG Ig Kappa Chain C Region EU Ig Kappa Chain C Region OU Ig Kappa Chain C Region TI Ig Kappa Chain C Region IGKCD Km
Location (GRCh38)
2:88857161-88857683
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
-
Sequence length
- nt
GC content
-
Summary

Predicted to enable antigen binding activity. Involved in adaptive immune response. Located in blood microparticle and extracellular exosome. Part of IgG immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in human skin wound healing identified the IGKC as a marker for plasmacytoid dendritic cells (pDC) [Liu et al. DOI:10.1016/j.stem.2024.11.013], while a separate bioinformatics analysis of human carotid atherosclerosis and Alzheimer's disease datasets used the IGKC as a marker for manual annotation of B cell clusters [Weiqi Xue et al. DOI:10.3233/JAD-230559].