This gene encodes a protein which has two immunoglobulin (Ig) domains and is a member of the immunoglobulin superfamily. Proteins in this superfamily are usually found on or in cell membranes and act as receptors in immune response pathways. [provided by RefSeq, Sep 2011]
Forensic Context
A study in rhesus macaques demonstrated that chronic ethanol self-administration broadly altered the brain transcriptome, identifying the IGSF21 as a key hub gene positively correlated with ethanol intake within the central nucleus of the amygdala coexpression network [Iancu et al. DOI:10.1111/Adb.12501]. Cross-species molecular analyses confirmed the IGSF21 as a conserved network hub correlated with ethanol consumption in macaque transcriptome studies [Farris et al. DOI:10.1016/J.Alcohol.2017.11.036].