Basic Information

Symbol
IL17B
RNA class
mRNA
Alias
Interleukin 17B IL-17B ZCYTO7 IL-20 NIRF Neuronal Interleukin-17-Related Factor Interleukin-17B MGC138900 MGC138901 Neuronal Interleukin-17 Related Factor Cytokine-Like Protein ZCYTO7 Interleukin-17 Beta Cytokine Zcyto7 Interleukin 20 Interleukin-20 IL20
Location (GRCh38)
5:149371324-149404202
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_014443.3
Sequence length
712.0 nt
GC content
0.6180

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-306.70 kcal/mol
Thermodynamic ensemble
Free energy: -319.21 kcal/mol
Frequency: 0.0000
Diversity: 134.04
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
....(((((((((((..(((....)))(((((((((((((((((((.((((((((((.((((((((..((((......)).))..)))))..(((((((((.(.(((((((..(((((((.(((...))))))))))(((((..............)))))..((((((((.(((((...)))))..))))..((((((((.(....).))))))))..((((......))))..))))..))))))).)..)))))))))((((.....)))).(((.(((((((((......)))..)))))).)))....))))))))))))).))))))))))(((....)))...((.((((.....))))))(((((((((((.....(((.((((...(((((..(((((.(......)))).)).)))))....).)))))))))))).)..)))).(((((((((.((....))...)))))))))(((.((.(((((.(((........))).))))))))))..)))))))))...((((......))))..))))))).....(((((.((((...)))).)))))(((((((.((((...((((((..((....))..)))))).))))...)))))))))))....(((.(((((((....))).))))..))).((.(.((((((........)))))).).))...
Thermodynamic Ensemble Prediction
...,((,,(((((((.,((({{{.,,,(((((((((((((((((((.((((((((((.((((((((..{({,...,,,}}.}}..}}}}},.(((((((((.{.(((((((,.(((((((((((...))))))))))(((((..............)))))..((((((((.(((((...)))))..))))..((((((((.(,...),))))))))..((((......))))..)))),.))))))).}..))))))))){(((.....)))),{((.(((((((((......))),.,))))),))}....))))))))))))).)))))))))){((....))}...({.((((.....))))}}((((,((((((..,..,((.{,,....{((((..({(((.(......)))).)).)))))..,})})}}))))))))}.,..)))).(((((((((.((....})...)))))))))(((.(,{(((((.(((........))).))))))))))..)))))))))...||||},....}))}..))))))).....(((((.((((...)))).)))))(((((((.((((...((((((..{(....}}..)))))).))))...)))))))}})}....,||.(((((((....)))},)))..}}}.,,.{.((((((........)))))).}.,},..

Transcripts

ID Sequence Length GC content
NM_001317987.2 NCBI
CUCAUUCUGUGAAGUGGCUUUUCUUUCCAGACUGGGAGAGGCAGCCUUG… 719 nt 0.6008
NM_014443.3 NCBI
AUUCUCUCGGCGGCAUCUGGGGUUCCAGGCGGGCAGCAGCUGCAGGCUG… 712 nt 0.6180
Summary

The protein encoded by this gene is a T cell-derived cytokine that shares sequence similarity with IL17. This cytokine was reported to stimulate the release of TNF alpha (TNF) and IL1 beta (IL1B) from a monocytic cell line. Immunohistochemical analysis of several nerve tissues indicated that this cytokine is primarily localized to neuronal cell bodies. Alternative splicing results in multiple splice variants. [provided by RefSeq, Dec 2015]

Forensic Context

A study in mice demonstrated that the IL17B gene is associated with a chromatin immunoprecipitation cluster enriched in long non-coding RNAs that are up-regulated following myocardial infarction [Ounzain et al. DOI:10.1093/eurheartj/ehu180]. A study in mice and humans demonstrated that the IL17B mRNA is a potential marker for vital reaction in skin contusions, with significantly higher levels in antemortem wounds compared to intact skin and postmortem injuries in both species, persisting for up to 72 hours after death [Ye et al. DOI:10.1016/j.jflm.2018.07.010].