Basic Information

Symbol
IL17F
RNA class
mRNA
Alias
Interleukin 17F IL-17F ML-1 ML1 Interleukin-17F Cytokine ML-1 CANDF6 IL17A
Location (GRCh38)
6:52236681-52245689
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_052872.4
Sequence length
813.0 nt
GC content
0.4748

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-233.10 kcal/mol
Thermodynamic ensemble
Free energy: -250.85 kcal/mol
Frequency: 0.0000
Diversity: 219.73
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
....(((.((((((((((((((.....(((...)))....)))))))......(((((((.((((.......(((((((.(((((....((((((...)))))).....)).)))...)))))))...)))))))))))(((((((.((.((((((((((((((((((......(((((.....)))))))))))..........)))))).))))))..)))))))))..(.((((.(((.......))).)))))..........((((..((((.((((......)))).))))..))))....(((...(((((......(((((((((((((((......))).))).....))).)).))))(((((((......)).))))).(((....)))....((((.((((..(((....)))..)))).))))..)))))...))).((((((....)))).)).(((......)))..(((((((((.(((.(.(((((((((....((((((.((.((.....)).))))))))))).)).)))).)..((((((((((.(((((((.((....(((((.....)))))..)).))).)))).))))).(((....))).....((((((((........................))))))))............)))))))).)))))))))............))))))).)))..(((((.....(((((((.(.(((..((.(((((((........))))))).))..)))).)))))))...)))))..............
Thermodynamic Ensemble Prediction
....{((.((((((((((((((.,.,.(({...}}}.,,,)))))))......(((((((.((((..,.,,,,({(((({({(((....((((((...)))))).....)).}))}}})))))}}...}))))))))))(((((((.((,((((((((((((((({{,.....,(((((.....))))))}}}}}..........))))))))})))).,)))))))))..|}|{||,|||,..,,,,|}}.}}}}},,}}......((((..((((.((((......)))).))))..)))).{,,((({,.(((((,.,{{{{{,((,,,,((((((......))).)))....}}})||),},,{(((((((......))}}))))}{{,....}}},...((((.((((..(((....)))..)))).))))..,,,}||,,|||.(({((({,.{||}}.))},|,}}},.}),}.)}|||||,,,}|||}}..))|},,|)}}..((((((.((.((.....)).)))))))).{{{{..{(({,{.,((((((((((.(((((((.((....(((((.....)))))..)).)))},))).))))).,,{,{,.}}),....((((((((..{,..................,,)))))))),,,....}}..,))))))).)))).)))).............))))))),))).,||.,,...,{{{((((({{,{,{,,,,.{{{{{{|........}}}},}},}}.,}}}}|}}}}}.....,))))}},...........

Transcripts

ID Sequence Length GC content
NM_052872.4 NCBI
GAACACAGGCAUACACAGGAAGAUACAUUCACAGAAAGAGCUUCCUGCA… 813 nt 0.4748
Summary

The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human postmortem brain tissue demonstrated that the IL17F mRNA was hypermethylated in the nucleus accumbens of subjects with alcohol use disorder compared to matched controls, with a mean methylation level of 0.556 in cases versus 0.250 in controls, and was identified among 26 hypermethylated mRNAs primarily involved in immune-related pathways such as IL-17 signaling [Liu et al. DOI:10.3390/genes13060958].