This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]
Forensic Context
A study in humans using platelet transcriptome data from patients with ST-segment elevation and non-ST-segment elevation myocardial infarction identified the IL17RE as a hub gene in a co-expression module significantly associated with STEMI, where it was functionally linked to cell membrane signal transduction [Zhang et al. DOI:PMC8129354].