Basic Information

Symbol
IL18
RNA class
mRNA
Alias
Interleukin 18 IL1F4 IL-18 IGIF IL-1g Interleukin 18 (Interferon-Gamma-Inducing Factor) IFN-Gamma-Inducing Factor Interleukin-1 Gamma Interleukin-18 Iboctadekin IL-1 Gamma Interferon-Gamma-Inducing Factor Interferon Gamma-Inducing Factor
Location (GRCh38)
11:112143251-112164106
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001562.4
Sequence length
1115.0 nt
GC content
0.4215

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-308.60 kcal/mol
Thermodynamic ensemble
Free energy: -329.42 kcal/mol
Frequency: 0.0000
Diversity: 276.07
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..(((((((((..(((....)))((((((((.((((.(((.((((((((((((.(((((((((((..((((.((((....)))).)))).)).)))((((((.((.((((((((....(((.((.((((((((.......)))).....)))).))..)))((((...((.(((((...))))).))))))..........((((((...)))))).))))...)))).)).....)))))).((((((((.((.....((((((((((......(((((((.((((......(((....)))))))))))))).................((((((((((...((((((......)))))).((((((.......(((.......))).....))))))))))))))))((((..((((.......))))...)))).((((((((...)))))))).....((((((.(((((.........)))))...))))))..)))))))))))).)))))))).(((((((.(((....)))...(((((((((...)))))))))(((((..((((...))))))))).............(((((..((...(((((.((((((......(((((...(((((.........))))).))))).....)))))))))))))..)))))....)))))))...((((((((.....))))))))...)))))).)))))))))))).)))....)))).)))))))).............................(((((.(((((((.((...((((....(((((((.((((((.(((((.((.(((((..((((((..((((((((...........))))))))....)))))).((..((.(((..((((............))))..)))))..))......))))).....))))))).)))))).))))).)))))).)).)))).))).).))))((((((((((.((((((...........)))))).)).)))).))))))).......))))))................................................
Thermodynamic Ensemble Prediction
..{(((((.,{,.(((....}}}((((((((.((((.(((.((((((((((((.((({,,((({(..((((.((((....)))).)))).}}.))){(({{{.{{,{({{(({,....,{{.{{,(({{((((.......}}}}...,}}}}}.}},,,}|((((...((.((((,...,)))).)))))),....,.,,,((((((...)))))).,},}..,||||,||...,,}}|}|},((({{{{|,||,.,..,,{((({{{{,,,,,.{{{{{{{.{{{{,.....{{{....)}}}}},}}}}}}}.,{,,.,..........((((((((((,{,{{((((......))))))}|(((((...,...(((.......))).....)))))})))))))))){{{{..{{||,,.....}))}...}}}}.((((((((...)))))))).....{{((((,(((((....,,}.,))))),..}}}}||,{|}|||||||||,.,,}}})),.{(((({{.,{,}}}},,....(((((((((...)))))))))(((((..((((...))))))))).......}}....|||||,,||,.}|||||{((((((...,..(((((...(((((.{{...,}.))))).))))).,...))))))))))}}},,}}},}...,)}))))).,||||{{,...{{,.|||},,,},,})))))).)))))))))))).)))....)))).))))))))....,.,.....,...........,..,||{{(({|{||{((((((((((((,...({((((({{...}}.))))).)))))))...((((((..(((((((({,,...,,,..))))))))....))))))((((((((((((.((({............})))..(((((((((((..{.(({{{({,..,,{{(((........)))))})))).,.)..))))},)))))).)))))).))))))...)))))))|{{{.{{{,...,})))})),.)))})))},.....)))))}................................................

Transcripts

ID Sequence Length GC content
NM_001243211.2 NCBI
CCUUUGCUCCCCUGGCGACUGCCUGGACAGUCAGCAAGGAAUUGUCUCC… 1103 nt 0.4216
NM_001386420.1 NCBI
CCUUUGCUCCCCUGGCGACUGCCUGGACAGUCAGCAAGGAAUUGUCUCC… 1136 nt 0.4208
NM_001562.4 NCBI
CCUUUGCUCCCCUGGCGACUGCCUGGACAGUCAGCAAGGAAUUGUCUCC… 1115 nt 0.4215
Summary

The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes. The inactive IL-18 precursor is processed to its active form by caspase-1, and is capable of stimulating interferon gamma production, and of regulating both T helper (Th) 1 and Th2 responses. This cytokine has been implicated in the injury of different organs, and in potentially fatal conditions characterized by a cytokine storm. In humans, IL-18 gene is located on chromosome 11. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2020]

Forensic Context

A study in humans using multi-level molecular data from monozygotic twin pairs identified the cytokine IL18R1 as elevated in heavier twins within an immunometabolism component [Kibble et al. DOI:10.1098/rsos.200872]. A study in preterm human newborns demonstrated that interleukin 18 (IL-18) was significantly increased in the cord blood of a sepsis group compared to controls, suggesting its potential diagnostic role in early-onset neonatal sepsis [Janec et al. DOI:10.14712/fb2023069050173]. A systematic review of wound-age estimation in human, rat, and mouse models noted that IL-18, a target of miR-203, is involved in cell proliferation and survival during wound repair, indicating its relevance in the molecular timeline of injury [De Simone et al. DOI:10.3389/fmed.2021.803067].