Basic Information

Symbol
IL3
RNA class
mRNA
Alias
Interleukin 3 IL-3 MCGF Hematopoietic Growth Factor MULTI-CSF Multipotential Colony-Stimulating Factor Multilineage-Colony-Stimulating Factor Colony-Stimulating Factor, Multiple P-Cell Stimulating Factor Mast-Cell Growth Factor Interleukin-3 MGC79398 MGC79399 Interleukin 3 (Colony-Stimulating Factor, Multiple) P-Cell-Stimulating Factor Mast Cell Growth Factor
Location (GRCh38)
5:132060655-132063204
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000588.4
Sequence length
924.0 nt
GC content
0.4762

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-254.50 kcal/mol
Thermodynamic ensemble
Free energy: -270.81 kcal/mol
Frequency: 0.0000
Diversity: 219.85
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((.......((((.(((.((..(.(((.(((.(((.((..........)).))).)))))))..)).))).))))............((((((...))))))....))))..((((((((((....((((..((.(((.(((((((......((((......((((.......................((((((.....(((((((..(((.((((..((.......))..)))).)))........(((.((.......)).))).(((.....))))))))))........))))))((((.((((.(((((((..((((...((((((....)))))).....(((((((.((...(((...))))).)))(((......))).((((...(((.......))).)))).((((((....))))))))))..)))))))....)))).)))).)))).....(((.((((((((.((....)))))))))))))))))....))))......))))))).))).)).))))...(((......)))..((((((..((..........))..))))))....)))))))))).(((((((((((((((((((((..(((.(((((...((((...((((..((((((((...((..(((.((.......(((((.((((((.(((........)).).))))))..(((((............))))).))))).......)).)))..))...))))))))..)))).)))).))))).)))..........((((((((((........))).)))))))..(((((((.....((((((.(((.........))).)))))))))))))...)))).)))).)))))))))))))...................
Thermodynamic Ensemble Prediction
{((({.....,.((((.(((.((..(.(((.(((.(((.((..........)).))).))))))}..)).))).)))),},.........((((((...)))))}...,},....((((((((((....((((,,((,{,{.{{((((({,..{{(((,,{{..{{....|||....,,,.......,}}.}||||,,.....{((((({{.{((.((((..((.......))..)))).))},|....|||{{.||.......}}.}))}}||}.,,,}}})),}}}},,},..,})))|}|((((.((((.(((({{(,.((((...{(((((....)))))).....((({(((.{(...({{...))))).)))(((......))).((((...(((.......))).)))).((((({....}))))))))}..))))})),,..}))).)))).))))|{{.{(((.((((((((.((....)))))))))))))).))||{{||||{{...{}}}}}}}.}}}.|}|||}}...{{,.,,..,)))..,{{|||,.||,,,.....{{||..,)))),....)))))))))).(((((((((((((((((((((..(((.(((((...((((...((((..((((((((.,.,,..,,{,,,......}|,,,,,((((({,{({,...,...})}).))))}}|.(((((............))))).||,.{,,..,.,|}.}}}.,}}...))))))))..)))).)))).))))).)))..........((((((((((........))).)))))))..(((((((.,.,.((((((,({(.....,,,,))).)))))))))))))...))))}}))).)))))))))))))........,.}})}.....

Transcripts

ID Sequence Length GC content
NM_000588.4 NCBI
AGAGCCCCACGAAGGACCAGAACAAGACAGAGUGCCUCCUGCCGAUCCA… 924 nt 0.4762
Summary

The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that the IL3 was one of the most induced genes in microglia at 60 days post-controlled cortical impact, indicating its role in the chronic phase of the neuroinflammatory response following traumatic brain injury [Izzy et al. DOI:10.3389/fncel.2019.00307].