Basic Information

Symbol
IL37
RNA class
mRNA
Alias
Interleukin 37 IL-1RP1 IL-1H4 IL-1F7 FIL1Z Interleukin-1-Related Protein Interleukin-1 Homolog 4 FIL1(ZETA) IL1F7 FIL1 Interleukin 1, Zeta Interleukin-37 FIL1 Zeta IL-1 Zeta IL1RP1 IL-1H IL-37 IL1H4 Interleukin 1 Family, Member 7 (Zeta) IL1F7 (Canonical Product IL-1F7b) IL-1F7b (IL-1H4, IL-1H, IL-1RP1) Interleukin 1 Family Member 7 Interleukin-1 Family Member 7 Interleukin-1 Superfamily Z Interleukin-1 Zeta Interleukin-23 IL-1X Protein IL-23 IL-1X
Location (GRCh38)
2:112911165-112918882
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_014439.4
Sequence length
864.0 nt
GC content
0.4815

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-281.30 kcal/mol
Thermodynamic ensemble
Free energy: -296.28 kcal/mol
Frequency: 0.0000
Diversity: 189.82
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...........((((((..(((........)))..((((.((((((((((((.(.((((..((((....)).))..)))).)..))))))))))))....(((((((((((((((.....))))))))..))))))).(((....)))))))..))))))(((((....((((((.....((((((............))))))((((((.....((((((((.(((.((((((((......(((((....((((((..((((((((((((....)))))......(.((((...(((.......)))...)))).)))))))).(((((((((........)))))))))..(((((((............)))))))............((.(((((((((((((((((((...((((((....))))....))...))))))))).((....)))).))).))))).)).......))))))..(((((........)))))((((....(((...))))))).(((((((.......))))).))....(((((((((((((((((....)).....))).))))))..)))))).......))))))))).)))))))........))))).)))))))))(((((((((..(((((((.((((...........)))))))))))..))))))))).......((((.((....(.((((...(((((.......)))))...)))).)....)).)))))))))).(((((((...(((.(((((........))..))).)))...)))))))..((((.((.....)).))))..............)))))...
Thermodynamic Ensemble Prediction
.{{{..(((.{((((((..(((........)))..}}||}||{(((((((((.(.((((..((((....)).))..)))).}..)))))))))}||....((((((({(((((((.....)))))))}..))))))){(({,...|||}}},..}}}}})}|||,....((((((,,,,.((((((............))))))((((((.....((((((((,((.{((((((((,.....(((((..,,{(((((..(((((((.(({(,{,,.|..,......{}||||.,,|,,......,||,...)))}.,))))))).(((((((((........)))))))))..(((((({..,,....,.,,})))))}............,,.||{(((({,{{||||||{,..{((((((....))))},..||{{{||,||||||.((....))..))))))))))})).......)))))).,(((((.{....}.))))){(((...,(({...}}}}))).{{(((((.......))))).}}....(((((((((((((((((....)).....))).))))))..))))))..,....))))))))).)))))})........))))).)))))))))(((((((((..(((((((.((((......,....}))})))))))..))))))))).......,{{({((,...(.{{{{...{{{{{.,,,,..))))}.{,||||.,.,}}))},,,,)))))).(((((((...(((.(((((........))..))).)))...)))))))..,{,,.,,....,||..,,...,......})),,}.,,,...

Transcripts

ID Sequence Length GC content
NM_014439.4 NCBI
AAGUAAAGGAUCCUGAGAACUGAAGGCAAACAGAGCUCCAGGAGUCCAA… 864 nt 0.4815
NM_173202.2 NCBI
AAGUAAAGGAUCCUGAGAACUGAAGGCAAACAGAGCUCCAGGAGUCCAA… 801 nt 0.4732
NM_173203.2 NCBI
AAGUAAAGGAUCCUGAGAACUGAAGGCAAACAGAGCUCCAGGAGUCCAA… 681 nt 0.4787
NM_173204.2 NCBI
AAGUAAAGGAUCCUGAGAACUGAAGGCAAACAGAGCUCCAGGAGUCCAA… 744 nt 0.4879
NM_173205.2 NCBI
AUGUCAGGCUGUGAUAGGAGGGAAACAGAAACCAAAGGAAAGAACAGCU… 652 nt 0.4663
Summary

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans demonstrated that the biomarker [IL37] serves as a skin marker for body fluid identification, with an average read count of 4,593 in skin tissue total RNA and 5,544 in surface skin swabs, detected in 2/3 and 2/6 donors respectively [Hanson et al. DOI:10.1016/j.fsigen.2018.02.020]. A study in humans demonstrated that the biomarker IL1F7 is a highly specific and sensitive mRNA marker for skin identification, detected down to 5 pg of input total skin RNA with no cross-reactivity observed with blood, semen, saliva, vaginal secretions, or menstrual blood at optimal inputs, and only weak expression was found in kidney tissue [Hanson et al. DOI:10.1016/j.fsigen.2012.01.004]. In a collaborative exercise analyzing human contact traces, IL1F7 was part of a skin-specific pentaplex and was detected in high-input skin samples but showed inconsistent detection in low-template contact traces [Haas et al. DOI:10.1016/j.fsigen.2015.01.002].