Basic Information

Symbol
IL6
RNA class
mRNA
Alias
Interleukin 6 IL-6 IFNB2 BSF2 HGF HSF B-Cell Stimulatory Factor 2 CTL Differentiation Factor Hybridoma Growth Factor Interferon Beta-2 Interleukin-6 IFN-Beta-2 BSF-2 CDF Interleukin 6 (Interferon, Beta 2) B-Cell Differentiation Factor Interferon, Beta 2 Interleukin BSF-2
Location (GRCh38)
7:22725884-22732002
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis Wound age identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000600.5
Sequence length
1127.0 nt
GC content
0.4250

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-305.10 kcal/mol
Thermodynamic ensemble
Free energy: -325.18 kcal/mol
Frequency: 0.0000
Diversity: 221.92
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
....((((....((((....((((..((.((((...)))).))))))(((((((((.((((..((((.....(((.((((((((.((((....(((((.(((((....(((.(((((...((((((..((..(((((((((((((............)))).))))...........))))).))..))).))).)))))..(((((((((.....((((((........)))))).......((((..(((......))).))))..)))))((((((.((....)).))))))))))...)))....))))))))))(((........)))..((.((....)).)).((((..(((((((....))).))))...))))..)))).).))))..))).)))..))))..)))).)))))))))(((((((((..((((.(.(...(((((((..(((((((((((((((.((......))(((((((((((((((((.......(((.((.......((((((((......(((...........)))....................((((........((((((..........)))))).........)))))))))))))).))).......)))).)))))))))))))(((((((.(((((((..((((((((((((((....((.......))..)))).))))))...))))))))....))).)))))))....(((.(((....))).)))((((((.((..((((.....((((((....))))))...)))).)).)).))))..)))))))))(((((....))))).........(((((.(((((((..(((.(((.......))).)))..))))))).))))).((((...))))...((((...))))....((((((((((((......(((.((......)).))).........))))))))))))))))))..))).)))).).).))))..))))))))).....)))).........(((((((....))))))).(((((((((....)))))))))....((((......))))......))))..............
Thermodynamic Ensemble Prediction
....((((....((((....((((..((.((((...)))).))))))(((((((((.((((..((((.....(((.((((((((.((((,,,,(((({{((((({(..(((,(((((.{.((((((..((..(((((((((((((............)))).))))...........))))).))..))).))).))))).,{{.{{({{{,,{..((((((........)))))).......{{{,..(((......))),))))...)))}((((((.((....)).)))))),|.....)}}....))))))))))(((........)))..{{.,(,...}},)).{(({..(((((((....)))},)))...)))}..)))).).))))..))).)))..))))..)))).)))))))))(((((((((..((((.(.(...(((((((..((((((((((((((({(({{{...||(((((((((((((((((.......(((.((.......((((((((......(({...........}}}............,,......((((...,,,..((((((.,......}.)))))).........)))))))))))))}.))).......)))),})))))))))))}.,||,||}|||{{{(,,(((,((((((((((....((.......))..)))).))))))..,}}}},}}}....||}.},}}}},....(((.(((....))).))){{||||.||..{(((.,{,,((((((....))))))...}}}).)).)}.,,}}..))))))))),{{{{....}}}},........,{((((.(((((((..(((.(((.......))).)))..))))))).})))}|.,{,...,}}|||.{{{{...}})).,,.((((((((((({..,.{{({{.{({,,...}),)),...,.}}}.))))))))))))))))))..)))}}))).).).))))..))))))))).....))))....{{{{.(((((({....})))))}.||||{{||{|||||||,}})))}}}.{(((......)))}......))))..............

Transcripts

ID Sequence Length GC content
NM_000600.5 NCBI
AUUCUGCCCUCGAGCCCACCGGGAACGAAAGAGAAGCUCUAUCUCCCCU… 1127 nt 0.4250
NM_001318095.2 NCBI
AUUCUGCCCUCGAGCCCACCGGGAACGAAAGAGAAGCUCUAUCUCCCCU… 936 nt 0.3942
NM_001371096.1 NCBI
AUUCUGCCCUCGAGCCCACCGGGAACGAAAGAGAAGCUCUAUCUCCCCU… 1058 nt 0.4083
Summary

This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). [provided by RefSeq, Aug 2020] CIViC Summary for IL6 Gene

Forensic Context

A study in rats demonstrated that the IL6 mRNA exhibited bimodal expression peaks at 4 and 20 hours following experimental fat embolization via triolein injection or femoral fracture, with its expression being significantly suppressed at 16 hours, and a weak correlation was observed between its mRNA levels and fat embolism severity in affected individuals [Kuwata DOI:10.1016/J.Legalmed.2024.102531]. In a separate investigation, UVB-induced inflammation in human and rat skin resulted in a significant up-regulation of the IL6 gene, with fold changes of 89.6 and 88.4 respectively, identifying it as a key inflammatory mediator at the peak of hyperalgesia [Dawes et al. DOI:10.1371/journal.pone.0093338]. A study in pigs demonstrated that in a long-term trauma model, the induction of hypothermia resulted in a significantly prolonged increase in local IL-6 levels within fracture hematoma at 24 and 48 hours compared to normothermic controls [Horst et al. DOI:10.1371/journal.pone.0154788].