Basic Information

Symbol
IL7
RNA class
mRNA
Alias
Interleukin 7 IL-7 Interleukin-7 IMD130
Location (GRCh38)
8:78675743-78805523
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000880.4
Sequence length
2016.0 nt
GC content
0.3775

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-491.90 kcal/mol
Thermodynamic ensemble
Free energy: -531.63 kcal/mol
Frequency: 0.0000
Diversity: 567.16
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.....((((((......)).))))....(((..(((((((...((((((((..(((..(.(((.((..((.((((.(((.((.((((((.((....)).))))))...((((......)))).((((((((((((.(((((.((((((........))))))))(((((((((..((((..(((((.((..((((((...(((.......(((((.....((........))....))))).....))).))))))...))..)))))..((((...(((..((((...))))..)))...))))........))))..)))....)).)))).((((((((((.(((((..(((((((...)))..)).))..)).))).).)))))))))))).))))))))))))((((........))))........)))))..)))).))..))..))))..))).)))))))))))))))(((((((.((((........))))))...(((((((...))))..)))))))).(((((((((((((...))))((((((((((((((...(((((((((.......((((((((((((((((((((((..(.((((((((((.(.((((((...((.......))...)))))).).)))..((((((((((......)))))....)))))))).))))..)..)))))))))...(((((......((((....((((((...((((((((((((................)))))))))))).....((((((.(((....((((((.....))))))..))).))))))(((.(((....))).)))......))))))))))..)))))(((((....))))).....(((((((..((((..........))))((.((((((((((...))))).((((((...(((((.(((((.......))))).......(((......))).....((((((((((.....)))))....)))))......)))))))))))..............)))))))......((((...........))))...(((((........((((((((..(((((.((((.((((((..((((....))))........((((....(((((...)))))))))((((((.((.(((((......)))))))))))))(((((.(.(((.(((((((.(........))))))))...))).)((((((.((((..(((......)))........((((((.((...(((((.((((((((((....))))))))))...)))))....)))))))).))))))))))..........)))))(((((...(((.(((((((((((.......))).)))))))).))).)))))...))))))....((((((.........))))))((((..(((((((....)))))))..)))).....((((.(((((.((......)))))))..))))))))))))).))))))))........))))).......))))))))))))))).)).)))..............((....))......)))))))))))))))))))))))........((((.....))))((((..(((((((.((((((...........(((.(((((..((((((....(((((.........)))))..))))))......................(((......))).))))).)))...)))))).)))))))..))))((((.(((((........))))).)))))))))).....)))(((((((...(((((((...(((((((((((.(.((......)).)))))))..)))))..)))))))...)))))))((((..(((...)))..))))((((........))))....))).(((((((..(((.((((......)))).)))..)))))))..
Thermodynamic Ensemble Prediction
.....((((((......)).)))).........(((((((...((((((((.,(({..(.(((,((..((,{(((,(((.,{.((((((.({....}).))))))...|||}|,,||,},|}|(((((((((((({(((({.((((((........))))))}}(((((.,,,..,||}},(((((,(,..((((((...(((.......(((((.,,..{(........)).,,.))))).....))).))))))...))..)))))..((((...(((..((({...))))..))).,.))))....,,,.|}}}..,}}}..,})})))|.((((((((((.(((({.((({(((....))).))).,...}),))).}.))))))))),),.))))))))))))||{{.|.,,...}})}........,.}}}}})))).)},,))..}|}}..))).))))))))}}}}}}|((((({(.((((........))))}}...({(((({...}))),.}))})))),|||||||||||||.,{||.{(((((((((((({,.{(((((((({,.....,,,{{,((((((((((((((((((,.(,((({{,{{{{}|.{|||||..,((....,|{}}...||||||,|,|||{{(((,,(((((......}}}}|.,,,||||}|||{|||,..,..|||||||})}.,|((((......{(({...,{{{{{{...((((((((((((....,.......,,..)))))))))))).....((((((.(({....((((({.....})))))..})).))))))(((.(((....})).))}......}}))))})))..}}}}|(((((....)))))...,,|.,||||||({{{..{{{{{{....||{|.((((((((((...))))).((((({,.,,{(((,,.......,,..(((({..{((((((.{{....,........}}.))|||)})..})))}.,,,,,,,,,...,..},,))))))))..............)))))}}..,,,||,|{{{{{{{..{((((,{(({.,.,{{,........,}}}},.))).,.)}}}}.,,......((((....))))}}})))}}.}}))...,}}}})}.,,,||,.,,{{{{{{,||.|||||.....,))))))))}}}|||{{|{,{|{,,.(((((((.(........}))))))}...,||,,.{{{{...,.,,))}}........,...||||||||,||},,.,,|||||.((((((((((....))))))))))..,||}}|,,,.,||}}||||||{|||||||,|,......,|{||.(((((...(((.(((((((((((.......))).)))))))).))).)))))...))},,....,||||{{.|},,,}},))))},{{({..(((((((....)))))))..)))}.,{{{.,.,{{{{,||,...{{{.((((.((((.,(((((...(((((,,..((({....))))....))))}...))))),)))).)))).))),,,..)}))},,,,..}|}}}}),..}}}})))))))))))))))))))))))}.......((((.....))))((((..(((((((.((((((...........(((.(((((..{{((((.,..{,,,.....,....}}}},..,...,.......................(((......))).))))).))),,,)))))).)))))))..)))),{{{.(((((........))))).}}}|{{..((((((((||(((((((,,.((({{{{,,.||{||||{|||.,..,......|,.|}}}}},.,})}}},.}}}}}}}...}}}}}||((((..{{,...,}}..))))}|,,...})))))))..))},))}{((((((..(((.((({......)))).)))..))))))}..

Transcripts

ID Sequence Length GC content
NM_000880.4 NCBI
ACACUUGUGGCUUCCGUGCACACAUUAACAACUCAUGGUUCUAGCUCCC… 2016 nt 0.3775
NM_001199886.2 NCBI
ACACUUGUGGCUUCCGUGCACACAUUAACAACUCAUGGUUCUAGCUCCC… 1884 nt 0.3763
NM_001199887.2 NCBI
ACACUUGUGGCUUCCGUGCACACAUUAACAACUCAUGGUUCUAGCUCCC… 1962 nt 0.3746
NM_001199888.2 NCBI
ACACUUGUGGCUUCCGUGCACACAUUAACAACUCAUGGUUCUAGCUCCC… 1830 nt 0.3732
Summary

The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. IL7 is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. IL7 plays an essential role in lymphoid cell survival, and in the maintenance of naive and memory T cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can be a potent inducer of proinflammatory cytokines and chemokines which may defend against the infection, but may also mediate destructive lung injury. Elevated serum IL7 levels, together with several other circulating cytokines and chemokines, has been found to be associated with the severity of Coronavirus Disease 19 (COVID-19). [provided by RefSeq, Jul 2020]

Forensic Context

A study in humans identified the IL7 as a cytokine significantly upregulated in mature B cells from patients with acute myocardial infarction and plaque rupture [Jun Qian et al. DOI:10.3389/fimmu.2022.908815], while another human study noted its role in binding to IL7R to mediate immune response in sepsis [Li et al. DOI:10.3389/fimmu.2024.1445858]. A review of mouse and human studies on myocardial infarction reported that the IL7 is secreted by post-infarction macrophages to induce cardiomyocyte apoptosis and enhance migration in vitro [Xinxin Bian et al. DOI:10.3892/mmr.2025.13680].