Forensic RNA Knowledge Base

Basic Information

Symbol

KCNK16

RNA class

mRNA

Alias

Potassium Two Pore Domain Channel Subfamily K Member 16 TALK-1 TALK1 K2p16.1 Potassium Channel, Two Pore Domain Subfamily K, Member 16 TWIK-Related Alkaline PH-Activated K(+) Channel 1 Potassium Channel, Subfamily K, Member 16 Potassium Channel Subfamily K Member 16 2P Domain Potassium Channel Talk-1 Pancreatic Potassium Channel Talk-1

Location (GRCh38)

6:39314698-39322968

UCSC Genome Browser Search in Marker Scope

Forensic tag(s)

Mechanical injury analysis Wound age identification

External database

HGNC

NCBI

Ensembl

OMIM

UniProt

GTEx

MANE select

Transcript ID

NM_001135106.2

Sequence length

1095.0 nt

GC content

0.6137

Secondary Structure

Generated by RNAfold

Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.

Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.

Minimum free energy

-474.40 kcal/mol

Thermodynamic ensemble

Free energy: -491.46 kcal/mol

Frequency: 0.0000

Diversity: 332.15

MFE Structure Visualization

Structure Prediction

MFE Structure Prediction

..(((((....)))))..............(((..(((((((((((.((.(((((((..(((.((((.(((((((....))))..)))))))....)))..))))))).)).)))).....((((((((((.....(((...(((((.(.(((((((((......((((((((((.......)))).)))))))))))))))).)))))...)))))))).)))))(((((.((..(((((((.((((((((....((((((((((.....)))))((((..(.....((((((((((((((((.......))))))).).))))))))......)..)))))))))..)))))..))).)))))))..)))))))(((((..((...))..)))))..(((....))).((((((.((((((.((((.(((((...)))))...)))).)).))))...))))))..)))))))..))).........((((..((((..((((...))))....((((.((((((.((.....(((......((((((....))))))..)))...)).)))))).))))......(((((..(((((((((...(((((((.(.((((......((.(((((((((.((.((((.(((..(((((.(((...))))))))(((.(((((((..(((((...((((((.(.(((......))).)))))))..(((((((((((((((.((((...(((((((....(((((((.......))))))).......))).)))).))))))))..)))))))))))(((((((........)))))))..........)))).)...))))))).))).((((...((.(((....)))))))))))).)))).)).).))))))))))(((((((.((((.(.((.((((.(((...))))))))).)...))))))))))).)))).)..))))))))))))).)))..)))))((((((((((.(((((((..(((........)))...))))))).....))))))))))((((....))))....))))..))))...

Thermodynamic Ensemble Prediction

{.(((({....})))},,{{,,((({..,{(.{.((((((((,(((,((((({(((({,(((.(((((({{((({.,,,))}}..{||||......}}},,))))},,|}},}}}....{{(,,,((((((,....|||..,|||{|,|.(((((((((......((((((((((.......)))).)))))))))))))))},)))))))}))}})))})})|||{((((.{(..(((((((.((((((((....((({,{{.....,,,((((((.(.,(,.,{..((((((((((((((((.......))))))).).))))))))},.)}.).))))))))))..))))),.))).)))))))..))))))).,||{,|{|{{{||{{||{|,.{((({{{..{{.((((((.((((((.((((.(((((...)))))...)))).)).))))...))))))..)})))||,..}},,..{{{{{,,,|}|||,,||||{,|}}))}}{,,,((((,,,||||.||,,}}}|||,.....((((((....))))))..})),,.,),))}))),)))}...,.}}},})))})}}|||(({.{((,,.,,))))||,...,.(((((((((((((((..((((({...,(((((.(((...))))))))))))))..,{((((((,....,))))))}.,)))).)))))))))),{{.{,((((((.....})))))|)).||(((((((....(((((((.......))))))).......))).)))).}),.,)))}..))))}|||||(((((((........))))))}}}}}.......,}}}}},,((((({{(((((({{(((((,........(((((({,.({((..((.......))..))))}))))))..(((....))}))))))))))))))))))},}}}..,},,((((((((||||.,..{(((((((.|,|,(((({..{|.,((((..,)))}}},,)}}}},|.,}}}})))),))}.))))))))}.{(((((({...,(({,....}))).,))))))),)}}}...

Transcripts

ID	Sequence	Length	GC content
NM_001135105.2 NCBI	GCACUGUUCAAACAGUCUCCCCAGCCUCCAGACACCUGUGCCGAGGAGG…	1557 nt	0.5812
NM_001135106.2 NCBI	GCACUGUUCAAACAGUCUCCCCAGCCUCCAGACACCUGUGCCGAGGAGG…	1095 nt	0.6137
NM_001135107.2 NCBI	GCACUGUUCAAACAGUCUCCCCAGCCUCCAGACACCUGUGCCGAGGAGG…	1255 nt	0.5857
NM_001363784.1 NCBI	CAGCCUUCAAGGGUGAAGACGCUGGGGGCGGCCGAGAGAGCCCACUGGG…	1139 nt	0.5645
NM_032115.4 NCBI	GCACUGUUCAAACAGUCUCCCCAGCCUCCAGACACCUGUGCCGAGGAGG…	1396 nt	0.5895

Summary

The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is expressed predominantly in the pancreas and is activated at alkaline pH. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Sep 2008]

Forensic Context

A study in mice demonstrated that spinal nerve ligation induced significant whole-transcriptome changes in injured dorsal root ganglia, with the KCNK16 being upregulated 6.80-fold six days post-injury [Wu et al. DOI:10.1177/1744806916629048].