Basic Information

Symbol
KLK1
RNA class
mRNA
Alias
Kallikrein 1 Klk6 Kidney/Pancreas/Salivary Gland Kallikrein Kallikrein 1, Renal/Pancreas/Salivary Tissue Kallikrein Kallikrein-1 EC 3.4.21.35 Kallikrein Serine Protease 1 Glandular Kallikrein 1 EC 3.4.21 KLKR HK1
Location (GRCh38)
19:50819146-50823787
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002257.4
Sequence length
876.0 nt
GC content
0.5731

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-332.00 kcal/mol
Thermodynamic ensemble
Free energy: -346.83 kcal/mol
Frequency: 0.0000
Diversity: 258.93
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
............((((((.....(((((.((.(((((((..(.(((((((((((((((((((((..((((...(((.(((...((((.((.(((((((....(((..(((..((((.((.((((((((((((.....)))))))))))))).)))).)))..)))..........(((((....)))))))))))...((((((...)))))).(((((.....((((.((((((((((..(((((.....(((((....))))))))))......(((((....)))))((((........))))....))).))))))))))).....))))).(((((......)))))....).)).))))..))).))).)))).))))).).))).(((((((((((.((.((((.(.....).))))..))))......((((((...))))))))))))))).(((((((.....((((.(((((..((......))..))))).)))).....)))))))...))))))).))))).)(((((....)))))..(((((.(((((((........))).((((..(((((.(.((......)).).))).))..))))((((.((........)).))))..))))))))).))))))).))......(..((((((.((((((((.((((((........(((((((.(((...(((((((((....(((((...))))).))))))))).......(((.(((((.......))))).)))((((..........)))).))).)))))))))))).)..))))))))))))))..).))))).......))))))...................
Thermodynamic Ensemble Prediction
.,..,,,,...,((((((,....(((((..,,{{|{{{{.,{{((((((((((((,(((({{(({{(,(({{{(,{.|||}}}{||||{,||{{(((({,,{({{..{{|,,|||{}||.((((((((((((.....))))))))))))}}.}||||,|||.||||,,,....,.{{{{{....}||||||||||{{{((((((...)))))}.|||||},...((((.((((((((((.,(((({.....(((((....)))))||||}.,,,...{{{{|,.,}}}..,|||,..,....)}))))}.))).))))))))))).,,,,))),}.||{{{......)))))..,})|}),})))..}},|))},)))).,)))).,.,},.(((((((((((.((.((((.{.....}.))))..))}},.....((((((...))))))})))))))).((({((({(...((,,.||,,,}}|||.}||.|)}|))))),}}}},|,,|}|})}}}||,}}}}}}|,||},.,}||{{{..,,})}}|..(((({.{{{||||..,,....}}).{{({..{{{{{.{.((......)).}.)))},}..})))||||,{(........)),})}}..}}}}|}}}}|||||,....},}}}},{,.((((((.((((((((.((((((,.......{((((((.(((...(((((((((....(((((...))))).))))))))).......(((.(((((.,...,.))))).))){(({..,......,))}}.))).)))))))))))).)..))))))))))))))..,.))))).....,.)))))}.........,,,,......

Transcripts

ID Sequence Length GC content
NM_002257.4 NCBI
AGUUCCUCCACCUGCUGGCCCCUGGACACCUCUGUCACCAUGUGGUUCC… 876 nt 0.5731
Summary

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008]

Forensic Context

A study in porcine skin exposed to bromine vapor demonstrated that the KLK1 transcript was significantly downregulated, with a 5.28-fold decrease after a 10-minute exposure and a 2.93-fold decrease after a 20-minute exposure, as identified via microarray analysis [Rogers et al. DOI:10.1002/jbt.20383]. A study in zebrafish and mouse demonstrated that the KLK1 transcript, a kallikrein 1-related peptidase, increased in abundance within 1 hour postmortem in mouse brain and liver tissues [Pozhitkov et al. DOI:10.1098/rsob.160267]. The research identified 1063 genes with significantly increased transcript abundances after death, functionally categorized into stress, immunity, inflammation, apoptosis, transport, development, epigenetic regulation, and cancer, indicating a step-wise shutdown process.