Basic Information
Symbol
KLRC1
RNA class
mRNA
Alias
Killer Cell Lectin Like Receptor C1
CD159a
Killer Cell Lectin-Like Receptor Subfamily C, Member 1
NKG2-A/NKG2-B Type II Integral Membrane Protein
CD159 Antigen-Like Family Member A
NKG2-1/B Activating NK Receptor
NKG2-A/B-Activating NK Receptor
NK Cell Receptor A
NKG2-A
NKG2-B
NKG2A
NKG2
NKG2-A/B Type II Integral Membrane Protein
Natural Killer Group Protein 2
Natural Killer Cell Lectin
C-Lectin Type II Protein
CD159a Antigen
Location (GRCh38)
12:10442264-10454685
Forensic tag(s)
-
MANE select
Transcript ID
NM_002259.5
Sequence length
1436.0 nt
GC content
0.3788
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-352.00 kcal/mol
Thermodynamic ensemble
Free energy:
-379.83 kcal/mol
Frequency:
0.0000
Diversity:
341.67
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...............((((.(((((...))))).((((((((...))))))))(((.(((((((((((..((((((((((((((((..((((...............((....))(((((..................))))).((((((...((.(((((((...((.((((((...........))))))))..)))))))))....)).))))........(((((...)))))..........(((((.(..........).)))))....))))...))))))).)))))...)))).....))))..))))))).)))...(((((.(((......((..(((..((((((((.(((......(((...........)))......((...(((.....))).))))).))))))))..)))..))..(((((((.....(((.((((.((((....(((..((((((((((((.(((((.....(((((..........))))).))))).((((......)))).......(((((...(((.((((...))))...))).)))))...((((........))))...))))))))))))..))))))).))))))).)))))))(((((((..(((((...((.((....)).)).)))))..)))))))...((.(((((.((((((((...)))))).))..)))))))....))).))))).((((((((((.(((((((((.(((((((((((((((((((......((((...((((((....(((((......((((((.(((((((((.((......)).))))((((((((((....((...((((.(((((.(((((..(((((((((((....(((((((((((...((((((....))))))...)))..)))))))).............((((((((((......))))))))))...((((.....)))).......(((((.(.(((((......))))).).))))).......))))))))....)))..)))))...............(((((..........)))))))))).))))...)).......))))))))))...((((..........))))...))))).))))))..))))).))))))))))......)))..))))))))(((((....((((........))))...)))))...(((((((............))))))).((((((((((((((((........))))))......)))))....))))).)))))))).))))).....)))))))))))))).......(((((...)))))......((((((...))))))(((((((.............)))))))....))))............
Thermodynamic Ensemble Prediction
...,,,,,,..{{,.{{{{,(((({{.,||}{{{((((,,,.}}}))))||||{..,...,{{{,||||,((((((((((((((((..((((...............{{....)}(((((...,,,......}},...))))).(((,,,...||,(((((((...((.((((((...........))))))))..)))))))}}...{||.||||,.,{,...{{||,.,,))))).....,,...(((((.,..........).)))))....)))}...))))))),,))))...)))}...(((((((((...(((......))}....{(,......||,,|.....(((((((((({......((((((((((((...(((((.,,,,..,|,,...,,|,}.},.{((,(({.((,{{{{(.((((((...{(({....}}}}}}}}),},))))))),))),)))},..)))))))))))))))))..........,(((.(((((((..{{.({{..((((..........)))).}})...}}..))))}})).))))))))))))))(((........)))..)))))))))..(((((((({(((..((..((((((.......)))))).))..))),,.,,....,,.||,||,.((((((((((......{((((.{,((((((...)))))).,,..))))).((((((((....)))}}))))((((....}))).,.(((....((((((((((((......((((...((((((....(((((......((((((.(((((({{{{(({,....|,,|}|,((((((((((.,,.((...((((.(((((.(((((.,(((((((((((....(((((((((((...((((((....))))))...)))..)))))))).,,..........((((((((((......)))))))))).,}{|{{,|||,|,||.......(((({.{.(((((......))))).).})))).......))))))))....))),.)))))...,,,....}},..(((((..........)))))))))).))))...))....,..))))))))))...,,||,,,.....}))))}},,))))).))))))..))))).))))))))))......))),.})))))))))))))))))))))....,}}})))))))))})),,))}})|}},..,,}}}}.,},,}}}}..{{(((((....,,,....(((((((({{(({.......{{,{..{{{{{,{({{{{{(({(((({....})))}.,,}}},,..}}}}))})}..}}}),,|,,,.,,,,,{{{||,,,,,})}}}}}}}}.)))))))).....,,,..))))}})),............
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| ACAGUUGAGAGGAGUUUGAGUGGAGAUUCAGGGCCAUUUUAGUAUCUUC… | 1179 nt | 0.4326 | |
| CCACUCUUGACUCACUCUGAGCCUUCACAGGGCAGUCUGCGAAGAUUGC… | 1436 nt | 0.3788 | |
| CCACUCUUGACUCACUCUGAGCCUUCACAGGGCAGUCUGCGAAGAUUGC… | 1382 nt | 0.3792 | |
| GUCUACAUUGAGACUACAGUUGAUAUGCCUACCUCCUGAGACACUAGUG… | 1446 nt | 0.3928 | |
| GUCUACAUUGAGACUACAGUUGAUAUGCCUACCUCCUGAGACACUAGUG… | 1500 nt | 0.3920 |
Summary
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jan 2015]
Forensic Context
No relevant information is available at the moment.