Basic Information

Symbol
KLRC3
RNA class
mRNA
Alias
Killer Cell Lectin Like Receptor C3 NKG2-E Killer Cell Lectin-Like Receptor Subfamily C, Member 3 NKG2-E Type II Integral Membrane Protein NKG2-E-Activating NK Receptor NK Cell Receptor E NKG2E
Location (GRCh38)
12:10412315-10420595
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002261.3
Sequence length
1025.0 nt
GC content
0.4020

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-235.90 kcal/mol
Thermodynamic ensemble
Free energy: -260.89 kcal/mol
Frequency: 0.0000
Diversity: 254.08
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((......(((((((((((......(((((.((((.(((((((((............((((.((((..(((.(((...(((((...(((........((((((......((((((...((((.............((((((((.((...(((....((((......))))....)))......)).))).)))))..(((((....)))))............)))).)))))).))))))))))))))...)))..)))..))))))))....))).))))))))))..)))))...)))))))...........(((((..((((......)))).))))).((((......)))).......(((((....((((((((.(((((.(((((.....((((((.......)))))).(((((((......(((((.((.(.((((.(((.((..(((((((..((((.((((....))))))))...)))))))))))).)))).).))..)))))....((((((...))))))(((((((..((((...(((((((((((.((((((((.......))))..))))))))))))).))...))))..).))))))((((..(((((...............))))).))))..)))))))))))))))))))).)))))..........((((((((.(((.((..((.(((((.........)))....)).))..))))).))))))))..((((...(((.((((((..........)))))).)))...)))).)))))......(((((((((.........((.((((....))))))....))))))))).......))))......)))).......................(((((......(((.((((((...((...((.(((((.(((((..((((((.((((.....)))))))))).)))))...))))).))...))..)))))))))......)))))...
Thermodynamic Ensemble Prediction
,,{(,,,,,,({(((((((((......(((((.((((.(((({{((({{..........((({,((((..,.,.(((((((((((...,{{.......{((((((......{(((((...((((........(((......)))........(({...,|||}..,,.}}|}....,}},,....,},}{(({({{....}},})))},,,},............)))).)))))).)))))))}})))),...})))))),..))))))))....,))}))))))))))..))))),..)))))))}..........(((((,.((((......}}}}.}}}}}.{(((,.....}}}},..,,,.{|{{{....(((({{,.||||({{({(((..,,,{(({(({{.....,,,))).{{{{||{|,,..}||,||}|,,|,||{{,||||||.,(((((((..((((.((((....))))))))...)))))))}||||,|}}|,|.||,,}}}}},,,.((((({...})))))(((((((..((({...(((((((((({{((((((((....,,,)}}}..))))))))))))).))...})))..)}}))))){(({..,,||||.........|{{{.,,,,,})))|,{||}}||||}}}}))}))),),))))},,.,....{{((((((((.(((.((..((.(({,,.........})),,..}}.))..))))).)))))))},)},,|...{,({,(((((..........)))))),}|||||}},,.})))),,,...(((((((((.........((.((((....))))))....))))))))).......,}},...,,,))}}......,{,,,..,,,,,},,,.{{{{{.....,{{,.{(((((...{{,,,{|.((((({((({(..((((((.((((.....)))))))))).)),))},.))))).}}..,)}..)))))},,),,....)))),...

Transcripts

ID Sequence Length GC content
NM_002261.3 NCBI
GCAGUUAUCAUAGAGCACAGUCCCUCACAUCACACAGCUGCAGAGAUGA… 1025 nt 0.4020
NM_007333.2 NCBI
GCAGUUAUCAUAGAGCACAGUCCCUCACAUCACACAGCUGCAGAGAUGA… 843 nt 0.3998
Summary

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans using single-cell RNA sequencing of peripheral blood mononuclear cells (PBMCs) from an irradiated patient and healthy controls identified KLRC3 as a gene marker highly expressed in specific natural killer (NK) cell subsets (NK3 and NK6), where it is involved in immune activation [Yan et al. DOI:10.3892/etm.2025.12846].