Basic Information

Symbol
KLRF1
RNA class
mRNA
Alias
Killer Cell Lectin Like Receptor F1 CLEC5C NKp80 Killer Cell Lectin-Like Receptor Subfamily F, Member 1 Killer Cell Lectin-Like Receptor Subfamily F Member 1 C-Type Lectin Domain Family 5 Member C Activating Coreceptor NKp80 Lectin-Like Receptor F1 ML
Location (GRCh38)
12:9827481-9845007
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_016523.3
Sequence length
1239.0 nt
GC content
0.3454

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-251.80 kcal/mol
Thermodynamic ensemble
Free energy: -278.31 kcal/mol
Frequency: 0.0000
Diversity: 385.28
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
......((((((((.....................))))).))).(((((((.........(((((((((((((.((((((((((((((..(((((((((((((((.....((((((((..((((((...................((((((..((((((......)))))).....))))))..((((((((((.............))))))))))..........(((((((((((.((....))....)))))))).)))........((((......((((((.(((.(((......((.(((((....(((.((((((..((((..((((.((..(.....................)..)).))))))))..)))))).))).(((((((((((...((((.......))))......(((((...........)))))((((....)))).....(((((......)))))....))))))))))).........)))))))......)))...))).))))))....)))).(((((((..........................)))))))))))))..)))......))))).....))))......((((((...(((....)))....)))))).((......))....((((..(((((.........)))))((((.((.....))..)))).......((((((...(((.(.(((((((.....(((((((((((((.........))))))))......(((((............)))))..(((((((...((((((.(.......(((((.........))))).......).))))))..)))))))..................)))))....))))))).).)))..))))))....))))(((....))).....)))))).))))).....((((((....(((((((.....(((((.......((((........)))).......)))))....)))))))...)))))).....)))))..))))))))).))))))))))))).........((((((..............))))))........(((((((..........((((.............))))......(((((........)))))......(((....))).........)))))))............))))))).........
Thermodynamic Ensemble Prediction
......{((((,,,.,,,.,....,..,,,....,|||||.||.,((((({{.,,,.,{{,{((((((((((((.((((((((((((({..{((((((((((((((,,,..{{((((({..({{{{,.,,,|,.............(((((({{((((((......)))))).}}}.,)))))..((((((((((.............)))))))))),,||,|||,,(((((((,,{,{(({.{{||{...,,|||||}..}}.}|.,,,.||||,..,}}|(({(({((,.((({.....,|}||,,|}}}}|||}|||||,..||||,|,....((((((({......,,,.....,,..,..,|}))))))),.{||||}}.}},.(((((((((((.,,((((.......))))......{({{{.,,...,.,..)))))((((....)))).....(((((......))))).,,.)))))))))))...,...,}))),,,,......|||...}}}.}},,||,...}|}}||||,..,,,,,,,.||{,,..,,..........}},))},))))))..}},,....}})})),....}}}),{{({{,.{|{{{({((({{{{.....|||.....,{,...}}}}.....{||||,||{,,...(((((({,({|((({{{..{{,{(((((,.....}))))},)}}.....)))}))})))))))...((((((((((((.........))))))))})))}.(((((.,,......,..))))}..,{{((({.,{(((((,.|,,,,|..{{{{,..,|{.,..||||{{{...{.{{|,,,,..})))))))}}}....,}}}},..,,,},,}},,,,,||.,.}})}}},...|||.|,.,,,.}})},............)))))).))))}.....{((((({{.,(((((,,....,|||{|,}}}}}}((((,,.....,}}}}...,,,.}}}}),...,,}}}))...))))))},,..)))))..))))))))).))))))))))))).,.......,,{{{{.,,,..........,}}||||.||{..,,,..,||}.},,}}}}}||}}.,},}}}......,,}|{,,,..,,|||}}......,}))),,,..,|||,,..|}|.........,,||,..............))))))),,,......

Transcripts

ID Sequence Length GC content
NM_001291822.2 NCBI
AUUUCAUGUUAUACUUAAUAAAACAAAACAUACCUGUAUACACACACAU… 1089 nt 0.3388
NM_001291823.2 NCBI
AUUUCAUGUUAUACUUAAUAAAACAAAACAUACCUGUAUACACACACAU… 836 nt 0.3325
NM_001366534.1 NCBI
AUUUCAUGUUAUACUUAAUAAAACAAAACAUACCUGUAUACACACACAU… 986 nt 0.3418
NM_016523.3 NCBI
AUUUCAUGUUAUACUUAAUAAAACAAAACAUACCUGUAUACACACACAU… 1239 nt 0.3454
Summary

KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009 [PubMed 18922855]).[supplied by OMIM, Oct 2009]

Forensic Context

A study in humans identified the KLRF1 as one of six key cluster-specific genes for distinguishing sepsis subgroups with distinct inflammatory responses and therapeutic strategies [Chen et al. DOI:10.3389/fimmu.2023.1298041].