Basic Information

Symbol
LCE1C
RNA class
mRNA
Alias
Late Cornified Envelope 1C LEP3 Late Cornified Envelope Protein 1C Late Envelope Protein 3
Location (GRCh38)
1:152804832-152806651
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_178351.4
Sequence length
718.0 nt
GC content
0.6086

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-279.40 kcal/mol
Thermodynamic ensemble
Free energy: -289.28 kcal/mol
Frequency: 0.0000
Diversity: 156.68
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((...(((((....)))))....((.((...)).))....(((....)))((((.((((.((.....(((((((((((((((((((((..(((.(((((..((((((((((....((((......))))(((.(...(((((.(((......)))(((((((.((((((((((..(((((((..((((((((....((((.(((..((((..(....)..))))..))).))))...))))))))..).)))....)))..)))))))))).......)))))))(((((((........)))))))...))))).).))).......(((((((.((((.(((..(((((((...)))))))..)))))))(((....))).))))))))))))).).)))..))))))))..)))).))))))...((((((.(((((((...((.((((...((((((..(((...))).((((.......)))).))))....)).))))))...)))))))..))))))((((((((((((..........)))))......))))))).(((.((((......((((((......)))))).......)))).)))((......))...((((........))))((..((..(((((.....)))))..))..)).....)))).).)))))))).))))..)))).........))).
Thermodynamic Ensemble Prediction
.(((...(((((....)))))..,..|}},{,{{{{{,{{,.(((,,..,|},{{{.{{{{.((,,,..(({{(((({((((((((((((..(((.(((((..(((,,(((((.,{.((((......)))){||.{...(((((.(((......)))(((((((.((((((((((..(((((((..((((((((....((((.(((..((((.,(...,)..))))..))).))))...))))))))..).)))....)))..)))))))))).......)))))))(((((((........)))))))...)))))...,))..,|.{{(((((((.((((.(((..(((((((...)))))))..)))})))|((....))}.))))))))))))),).)))..))))))))..)))).))))))...((((((.(((((((...((.((((...((((({..(({...})).{(((.......)))}.))))....)).))))))...)))))))..))))))((((((((((((..........)))))......))))))),((({((((......((((((......))))))||,....,))),,}})))}.,,..,,,.||||,.......}}}}||..((..(((((.....)))))..))..)},,,..)))),}.}}}}}})).)}}}..)))).....,,..))..

Transcripts

ID Sequence Length GC content
NM_001276331.2 NCBI
AUCCACUCACCUCCCGAGGUGCUGAAGGACCCUGUGCUGCCUGUGACCC… 628 nt 0.6051
NM_178351.4 NCBI
AUCCACUCACCUCCCGAGGUGCUGAAGGACCCUGUGCUGCCUGUGACCC… 718 nt 0.6086
Summary

Predicted to be involved in keratinization. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans demonstrated that the biomarker LCE1C is a highly sensitive and specific mRNA marker for skin identification, detectable down to 5 pg of input total RNA from skin and in swabs of touched objects [Hanson et al. DOI:10.1016/j.fsigen.2012.01.004]. Further research confirmed its utility for inferring the skin origin of touched contact traces, as it was successfully detected in mock casework samples like mobile phones and keyboards, though its expression level did not correlate with DNA yield [Akutsu et al. DOI:10.1016/j.legalmed.2018.05.003]. Furthermore, research in human skin showed that expression of the LCE1C decreases in a time-dependent manner, making it useful for early post-mortem interval estimation up to five days [Scrivano et al. DOI:10.1007/s00414-019-02125-x].