Basic Information

Symbol
LCE1D
RNA class
mRNA
Alias
Late Cornified Envelope 1D LEP4 Late Cornified Envelope Protein 1D Late Envelope Protein 4
Location (GRCh38)
1:152796721-152798181
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_178352.3
Sequence length
460.0 nt
GC content
0.6435

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-201.90 kcal/mol
Thermodynamic ensemble
Free energy: -208.75 kcal/mol
Frequency: 0.0000
Diversity: 70.49
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.....((((((......(((........)))((.(((((.(.(.(((((((....((......))....)).)).)))).).))))).))...((((((((...((((((((....((((((((....)))))))).......((((.(((.......(.(((((..(((((((..((((((((....((((......))))...))))))))..).)))....)))..))))))))).).))).........(((((((((((((((((((((((((((((((........)))))))))..(((..((.(((...))))))))...))))))).........))))))).))))))))))))))))...))))))))))))))((((((((((..((...))..))))))))))((((.(((........))).))))......((((.....)))).
Thermodynamic Ensemble Prediction
..,,,((((((,....}|||}.......,,}((.(((((.{.(.(((((((.,..((......}}....)).)}.)))).).))))).))...((((((((...((((((({....((((((((....)))))))).....{.((((,(((.......(.(((((..(((((((..((((((((....((((......))))...))))))))..).)))....)))..))))))))}.).)))........,(((((((((((((((((((((((((((((((........)))))))))..({(,.{{.(({...}))}}}))...)))))))}}.......,,})))),})))))))))))))))...))))))))))))))((((((((((..({...})..))))))))))((((.(((........))).))))......((((.....)))).

Transcripts

ID Sequence Length GC content
NM_178352.3 NCBI
AUCCACUCACCUCCUGAGGUGCUAAAGAACCCUGUGCUGCCUGUGACUC… 460 nt 0.6435
Summary

Enables identical protein binding activity. Involved in cognition. Acts upstream of or within cellular response to calcium ion. Located in cornified envelope and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans identified the LCE1D as a skin-specific mRNA marker, demonstrating high specificity for skin with no cross-reactivity to other body fluids at an optimal input of 5 ng [Hanson et al. DOI:10.1016/j.fsigen.2012.01.004]. A subsequent collaborative exercise confirmed its detection in high-input skin samples but noted inconsistent detection in low-template contact traces, supporting its use in RNA/DNA co-extraction strategies for forensic tissue identification [Haas et al. DOI:10.1016/j.fsigen.2015.01.002].