Basic Information

Symbol
LCE2D
RNA class
mRNA
Alias
Late Cornified Envelope 2D LEP12 SPRL1A Small Proline-Rich-Like Epidermal Differentiation Complex Protein 1A Small Proline Rich-Like (Epidermal Differentiation Complex) 1A Late Cornified Envelope Protein 2D Late Envelope Protein 12
Location (GRCh38)
1:152663380-152664659
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_178430.4
Sequence length
625.0 nt
GC content
0.5664

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-218.60 kcal/mol
Thermodynamic ensemble
Free energy: -229.33 kcal/mol
Frequency: 0.0000
Diversity: 155.17
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.....(((((......)))))....(((.(.((((((((((((((...((((((.....(((.((((..((.(((.......)))...)).)))).)))..))))))..((((...(((((.((((.(((.((........)).))).((((((((.........((..(((((((((((.(((((..(((.((((.(((((((((....((((((((......(((.((((((((.((((((((.......)))))))).)))))))).)))(((((((((........))))))))).(((.(((..........))).)))(((((((((((((((((((((.....)))))....)).)))).)))))).))))))))))))...))))))))).).......)))..)))...)))))..)))))))..)))).........))........)))))))).............................)))).))))))))).(((((((..((.(((((...))))))).)))))))..(((.((((......(((.((...)).)))....)))).)))..))))).))))..))))).).))).............
Thermodynamic Ensemble Prediction
...,((((((......}}}||,|{.(((.(,(({{{{||||{{||,..((((((.....(((.((((..((.(({,,.....)))...)).)))).)))..))))))..,,,,...|||||,{,{{,({{..{{{,....{({{((({((((((...........,...({{{(((((((.(((((..(((.{(({.(((((((((....((((((((..,,{{(((.((((((((.((((((((.......)))))))).)))))))).))}(((((((((........))))))))).(((,(((,.......,.})).)))((({((((((((((({{{(((.....)))))....}}.))))}}))))).)))}))))))))...))))))))).}.......)))..)))...)))))..)))))))..)))},........{,...{||..,,,))}.........................))))..))))}))))))))}.(((((((..((.(((((...))))))).))))))),,||..||||,}...,|{{.((,,,},.}},....}},}.,|,..}}}}}.,))),.,}))).}.}}}....,........

Transcripts

ID Sequence Length GC content
NM_178430.4 NCBI
AUCUGCUCUGACUCCCCAGGGACGUGUCUGUGCUUUUGCAUGUGACCAG… 625 nt 0.5664
Summary

Predicted to be involved in keratinization. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans demonstrated that the LCE2D is a skin-specific mRNA marker, part of the skin1 pentaplex, which was successfully detected in high-input skin samples but showed inconsistent detection in low-template contact traces like fingerprints and touched objects [Hanson et al. DOI:10.1016/j.fsigen.2012.01.004]. In a collaborative exercise, the LCE2D was detected in a skin RNA dilution series down to 0.8 ng input, though its expression in actual contact traces was sporadic, reflecting sensitivity limits in trace evidence [Haas et al. DOI:10.1016/j.fsigen.2015.01.002].