Basic Information

Symbol
LGALS3
RNA class
mRNA
Alias
Galectin 3 GALIG Advanced Glycation End-Product Receptor 3 Lectin, Galactoside-Binding, Soluble, 3 Carbohydrate-Binding Protein 35 Galactose-Specific Lectin 3 Laminin-Binding Protein IgE-Binding Protein 35 KDa Lectin Lectin L-29 Galectin-3 LGALS2 MAC-2 GALBP MAC2 Epididymis Secretory Sperm Binding Protein Galactoside-Binding Protein MAC-2 Antigen Mac-2 Antigen CBP 35 CBP35 Gal-3 GAL3 L-31 L31
Location (GRCh38)
14:55121352-55148022
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002306.4
Sequence length
958.0 nt
GC content
0.5052

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-332.90 kcal/mol
Thermodynamic ensemble
Free energy: -350.72 kcal/mol
Frequency: 0.0000
Diversity: 221.16
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((.((((((((((.((((((..((((((((((....((((..(((((((((((........)))))))))))..))..))....)))((((.(((....))).))))....)))))))))))))...)))))........)))))))))...((((..(((((((........))))))))))).(((((((((((((...((((((.....))))))..((((..(((((((.(((((...))).)).)))))))....(((.((.((....)).)).))).....(((((((((.......)))))))))))))..(((.....))).((((...((((((..((.(((............))).))..))))))....))))(((.((.....)))))........))))..)))))))))(((.((((..((((.((.(((((.((((((((.(((.(((...)))...)))...)))))))).....(((((.(((.((((((.(((((....(((((.((((..(((...((((.............))))(((.(((((((((........)).))))))).)))))))))))))))....(((((.(((((.((((((....))))))))))).............((((((....(((((((.....)).)))))(((((((.......)))).)))..))))))..((((.(((((....))))).))))..((((....))))(((...(((((((........)))))))...))).............(((((((.......)))))))............((((..(((((((((....)).)))))))...)))))))))..(((((....)))))...)))))...))))))))).)))))..............)))))))))))..))))...)))..
Thermodynamic Ensemble Prediction
,{,,{((((,(((((.((((((..((((((({((,,..,{{{..(((((((((((......,.)))))))))))..}}.,),,,..}),((((.(((....))).))))....)))))))))))))...))))).....},.)))||||||(((((((..(((((((........))))))))))).(((((((((((((...((((((,,...|||}||..((((..(((((((.(((({...})).)).))))))).,..|||.||.{{....)).)),))}.....(((((((((.......)))))))))}}},..(({.....})).((((...((((((..((.(((............))).))..))))))....))))((|{({.....)))))........)))),.,)))))))).,,{(({({.((((.(({({(,..,,,{{{{{}|||.,||,,.)))),.,||{,.,,,,,)))}....(((((.(,{{((((((.{((((((.,(((((.((((..((({.,((({..{{..,,,,...}}}},{|.{||||||{{......,,)),))})}}}.}}})))))))))))}...}|||,|,((((((((((({....})))))))))).............((((((,,..((((({{.....}},})))}(((((((.......))))},}}.,))}}))..((((.(((((....))))).))))..{{({....}}}|{{,...(((((({........))))))),},)}|,,.....,}}}..(((((((.......)))))))............{{{{..(((((((((....))}}}))))).,.}})}|||||{{((({{....})),)}},)))}}...))))))))}.)))))...,{{{{{{{....}))),))))}....)))))))),.

Transcripts

ID Sequence Length GC content
NM_001357678.2 NCBI
GCCCGCAGCACCUCCUCGCCAGCAGCCGUCCGGAGCCAGCCAACGAGCG… 999 nt 0.5065
NM_002306.4 NCBI
GCCCGCAGCACCUCCUCGCCAGCAGCCGUCCGGAGCCAGCCAACGAGCG… 958 nt 0.5052
Summary

This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014]

Forensic Context

A study in mice demonstrated that the LGALS3 gene was significantly upregulated in myocardial tissues following acute myocardial infarction and was identified as a core monocyte/macrophage-associated hub gene [Yang et al. DOI:10.2147/JIR.S516092]. In human postmortem brain tissue from subjects with opioid use disorder, the LGALS3 protein and its corresponding RNA were both significantly upregulated in the dorsolateral prefrontal cortex, with its protein levels validated by ELISA, and it was implicated in pro-angiogenic networks and increased endothelial cell proliferation [Mendez et al. DOI:10.1038/s41380-021-01259-y]. A review of human studies notes that the LGALS3 reflects myocardial fibrosis and elevated levels are associated with a poorer prognosis in chronic heart failure [Raluca-Maria Cătinas; Sorin Hostiuc DOI:10.3390/ijms26146818].