| ID | Sequence | Length | GC content |
|---|---|---|---|
| GCAUUUCUCCUCUGUGCUCAUUGCCACAUGCAGCUCAGCCUGGGCUACA… | 1390 nt | 0.5576 | |
| GCAUUUCUCCUCUGUGCUCAUUGCCACAUGCAGCUCAGCCUGGGCUACA… | 1108 nt | 0.5785 | |
| GCAUUUCUCCUCUGUGCUCAUUGCCACAUGCAGCUCAGCCUGGGCUACA… | 1354 nt | 0.5532 | |
| GCAUUUCUCCUCUGUGCUCAUUGCCACAUGCAGCUCAGCCUGGGCUACA… | 1072 nt | 0.5737 |
The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
A study in humans and mice demonstrated that the LILRA5 is a key diagnostic marker for sepsis, identified through machine learning algorithms and validated across multiple external datasets and clinical samples with high AUC values [Ning et al. DOI:10.07/s10753-023-01803-8].