Basic Information

Symbol
LIPT1
RNA class
mRNA
Alias
Lipoyltransferase 1 Lipoyl Amidotransferase LIPT1, Mitochondrial Lipoate Biosynthesis Protein Lipoyl Ligase MGC12290 MGC13378 Lipoyltransferase 1, Mitochondrial Lipoate-Protein Ligase EC 2.3.1.200 EC 2.3.1.- LIPT1D
Location (GRCh38)
2:99154955-99163179
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_145199.3
Sequence length
1266.0 nt
GC content
0.3894

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-305.80 kcal/mol
Thermodynamic ensemble
Free energy: -329.71 kcal/mol
Frequency: 0.0000
Diversity: 340.97
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..((((((.(((((((..(((((((((((..((...(((((.(.(((.((((..(((....))))))).)))).)))))..))..))))).)))))).........(((((((((....))))).))))))))))).))))))....(((((((..........((((((......((((((...(((((((.((((((...(((((((((((((....(((.((((((........)))))).)))...(((..(((((((....))..))))))))....((((((........))))))....)))))))))))))...(((..(.(((...((((.(((...(((......)))...)))))))...))).)..))).......(((..((((((.((((.....((((((.....))))))....))))))))))....)))..............(((........))))))))).)))))))))))))....))))))......)))))))....((((((...(((((((((((.....((((((....(((..((.....((((.((((.....)))).)))).(((.(((..((..(((((((..((((((........))))))..)))))))..))))).))).....((((...((.(((((...))))).))...))))((((........))))))..)))..)))))))))))))))))....((...))((((((....((((((((........)))).))))..))))))(((.((.((((((......)))))).)))))............((....))((((((((..((((..(((..............)))..))))(((((((((.(((((..............))))).)))))).)))......(((((.(((.((((((.((((((.......((((........)))).))))))))))))..))).)))))((((((((((.(((........(((((........)).)))..((((((.(((((((((.......(((((((..((((((((...((((((........))))))....)))))......)))..)))).)))..)))).......(((...(((....)))...)))..((((((((............))))))))))))).)))))).............)))))))))))))...........)))))))).))))))
Thermodynamic Ensemble Prediction
..((((((,(((((((..(((((((((((..((...{((((.(.(((.((((.,(((....))))))).)))},)))))..))..))))).)))))).........(((({{{{(,,..}||||.|}}}))))))).})))}}..{{((((||(|,{,.....,((((((.....,{(({{{,{{((((((({({{{{{...(((((((((((({..,.(((.{(((((........)))))}.))}.,,{{{,.{((((((....))..}))))}}}...,((((((........)))))},.,.)))))))))))))...(((..(,(((,,,(((.((((...(((......)))...))))}},...|||,|.,}}}..,{..{(((.,((((({.((((.....((((((.....))))))....)))))))))).,..}},.............,{{{..,.....})}),,,},.,||}|||||}}},,,..,|||||{{{...,,|||||,,,,,|||||}|.,{{{{{{{|||...,|||||{|.|.}|||}}||,,....|||}|{||...,})))).,}}},|||}||,...,..(((((((..((((((........))))))..))))))),})))))})))..,,{((((...({.(((({...})))).}),,,}}}}{(((........)))}.,.||||,,||||},,,}}}}}}})),,,}|},,..,{{,,||,..,}}}}|||,},......})))}}),,..}))))),|)))}}|(((((......)))))}...,....................|}{(((((({.,((((..{{{........,..,..}}}..}}}}(((((((({.(((((..............))))).}))))).))}......(((((.(((.((((((.((((((.......((((........)))).))))))))))))..))).)))))(((((((({{{(((.,,,,,,.(((((........))}}))..{(((((.(((((({{,.......,,,,,||,.{,(((((({,.((((((,......,)))))),,..)))))}.....,,,.,||||.|},..}|||.....,,{{{...{{{....)))...))}..((((((((.........,..))))))))})))).))))))......,,..,,.)))))))))))))...........)))))))).))}},.

Transcripts

ID Sequence Length GC content
NM_001204830.2 NCBI
AAACCGGGAUGUUGCGGGCCGUAGCGCGUGGGCGGCCGUGGGGUCUUGG… 1602 nt 0.4282
NM_015929.4 NCBI
AAGGCCUGCCGGUUGCUCGGGGUCGUAUGACGCACUUUUCCAGCUCGAG… 1392 nt 0.4102
NM_145197.3 NCBI
AAGGCCUGCCGGUUGCUCGGGGUCGUAUGACGCACUUUUCCAGCUCGAG… 1520 nt 0.4013
NM_145198.3 NCBI
AAGGCCUGCCGGUUGCUCGGGGUCGUAUGACGCACUUUUCCAGCUCGAG… 1508 nt 0.4191
NM_145199.3 NCBI
AAGGCCUGCCGGUUGCUCGGGGUCGUAUGACGCACUUUUCCAGCUCGAG… 1266 nt 0.3894
Summary

The process of transferring lipoic acid to proteins is a two-step process. The first step is the activation of lipoic acid by lipoate-activating enzyme to form lipoyl-AMP. For the second step, the protein encoded by this gene transfers the lipoyl moiety to apoproteins. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 13. Read-through transcription also exists between this gene and the neighboring downstream mitochondrial ribosomal protein L30 (MRPL30) gene. [provided by RefSeq, Mar 2011]

Forensic Context

A study in humans identified the LIPT1 as a key differentially expressed cuproptosis-related gene (DECuG) in sepsis, where it was significantly dysregulated in validation cohorts and showed a major distribution in monocytes, T cells, B cells, and NK cells at the single-cell RNA level [Wang et al. DOI:10.1016/j.heliyon.2024.e27379].