Enables actin monomer binding activity and tropomyosin binding activity. Involved in actin nucleation; positive regulation of actin filament polymerization; and sarcomere organization. Located in M band and actin filament. Implicated in dilated cardiomyopathy 2G. [provided by Alliance of Genome Resources, Jul 2025]
Forensic Context
A study in human postmortem cardiac tissue identified LMOD2 as a significantly downregulated RNA biomarker associated with SUD-SCZ pathogenesis, contained within a key cardiomyocyte co-expression module [Chen et al. DOI:10.1016/J.Forsciint.2025.112646].