Predicted to be involved in long-term memory. Predicted to act upstream of or within visual learning. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Forensic Context
A study in rhesus macaques demonstrated that the LRRN4 transcript was upregulated among common differentially expressed genes in irradiated lungs, identifying it as a potential biomarker for radiation-induced lung injury [Thakur et al. DOI:10.1016/j.ijrobp.2021.03.058]. In humans, a separate investigation of subcutaneous adipose tissue during long-term weight loss found that the LRRN4 gene was upregulated in weight losers over a 12-month period, with its expression pattern being reciprocal to that observed in acquired obesity [Bollepalli et al. DOI:10.1038/ijo.2017.245]. A study in rhesus macaques demonstrated that the LRRN4 was significantly upregulated among common differentially expressed genes in lung tissue following whole-thorax irradiation, identifying it as a potential biomarker for radiation-induced lung injury [Priyanka Thakur et al. DOI:10.1016/j.ijrobp.2021.03.058].