Basic Information

Symbol
APOA2
RNA class
mRNA
Alias
Apolipoprotein A2 Apolipoprotein A-II Apo-AII ApoA-II ApoAII
Location (GRCh38)
1:161222290-161224305
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Chronological age estimation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001643.2
Sequence length
474.0 nt
GC content
0.5338

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-140.00 kcal/mol
Thermodynamic ensemble
Free energy: -147.70 kcal/mol
Frequency: 0.0000
Diversity: 83.95
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((.(((......((((((.((.(((..(((((..........((.((((...)))))).((((((((..((((....)))).....((((..((((.((..((((.((((((..(((((..(.((((((......))).))).)...))))).))))))))))..))..))))..))))..((((.((((..((.(((((.(.....(((.....))).....).)))))))...))))))))...((((((....))))))))))))))(((((.((((.......((((((..((((((..(.((((....)))).)..)))))).............))))))......))).)..))))).((((....))))..........(((((((...............)))))))))))))))))))))))........))).)))).......................
Thermodynamic Ensemble Prediction
.((((.(((......((((((.((.(((..(((((..,.,.....{{.((({...})))}}.(((((((({.((({....)))}.,...((((..((((.{(..(((,{((((((..(((((..(.((((((......))).))).)...))))).))))))))))..})..))))..))))..((((.((((..((.(((((.(.....(((.....))).....).)))))))...))))))))...((((((....)))))))))))))),.|,....,,.{{{{{{{({{(({.,,,,,,,}|}|{..}}}})))).}..,,}})|||...,{(({,(((..((((.....))).)..))))))||{|....)))},,,.......(((((((....,..........)))))))))))))))))))))))........))).)))).......................

Transcripts

ID Sequence Length GC content
NM_001643.2 NCBI
AGGCACAGACACCAAGGACAGAGACGCUGGCUAGGCCGCCCUCCCCACU… 474 nt 0.5338
Summary

This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human blood plasma demonstrated that the APOA2 was significantly downregulated with age and was used as a protein biomarker for building age-predictive models [Salignon et al. DOI:10.18632/aging.204787].